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5u85

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'''Unreleased structure'''
 
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The entry 5u85 is ON HOLD until Paper Publication
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==Murine saposin-D (SapD), open conformation==
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<StructureSection load='5u85' size='340' side='right' caption='[[5u85]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5u85]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U85 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U85 FirstGlance]. <br>
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Description:
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u85 OCA], [http://pdbe.org/5u85 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u85 RCSB], [http://www.ebi.ac.uk/pdbsum/5u85 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u85 ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/SAP_MOUSE SAP_MOUSE]] Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.<ref>PMID:23690594</ref> Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.[UniProtKB:P07602] Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.[UniProtKB:P07602] Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).[UniProtKB:P07602] Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.[UniProtKB:P07602]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Gebai, A]]
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[[Category: Gorelik, A]]
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[[Category: Illes, K]]
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[[Category: Nagar, B]]
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[[Category: Hydrolase]]
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[[Category: Saposin]]

Revision as of 07:31, 14 June 2018

Murine saposin-D (SapD), open conformation

5u85, resolution 1.65Å

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