5w4f

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'''Unreleased structure'''
 
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The entry 5w4f is ON HOLD until Paper Publication
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==Importin binding to pol Mu NLS peptide==
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<StructureSection load='5w4f' size='340' side='right' caption='[[5w4f]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
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Authors: Pedersen, L.C., London, R.E.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5w4f]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W4F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W4F FirstGlance]. <br>
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Description: Importin binding to pol Mu NLS peptide
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5w4e|5w4e]], [[5w4g|5w4g]]</td></tr>
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[[Category: Pedersen, L.C]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
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[[Category: London, R.E]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w4f OCA], [http://pdbe.org/5w4f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w4f RCSB], [http://www.ebi.ac.uk/pdbsum/5w4f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w4f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE]] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. [[http://www.uniprot.org/uniprot/DPOLM_HUMAN DPOLM_HUMAN]] Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination.<ref>PMID:12640116</ref> <ref>PMID:12888504</ref> <ref>PMID:17483519</ref> <ref>PMID:17915942</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: DNA-directed DNA polymerase]]
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[[Category: London, R E]]
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[[Category: Pedersen, L C]]
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[[Category: Importin]]
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[[Category: Nl]]
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[[Category: Nuclear transport]]
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[[Category: Protein binding]]
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[[Category: Tdt]]

Revision as of 07:33, 14 June 2018

Importin binding to pol Mu NLS peptide

5w4f, resolution 1.98Å

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