2j8k
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 2j8k |SIZE=350|CAPTION= <scene name='initialview01'>2j8k</scene>, resolution 1.50Å | |PDB= 2j8k |SIZE=350|CAPTION= <scene name='initialview01'>2j8k</scene>, resolution 1.50Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2j8i|2J8I]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8k OCA], [http://www.ebi.ac.uk/pdbsum/2j8k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2j8k RCSB]</span> | ||
}} | }} | ||
| Line 26: | Line 29: | ||
[[Category: Hegde, S S.]] | [[Category: Hegde, S S.]] | ||
[[Category: Vetting, M W.]] | [[Category: Vetting, M W.]] | ||
| - | [[Category: MES]] | ||
| - | [[Category: SO4]] | ||
[[Category: nostoc punctiforme]] | [[Category: nostoc punctiforme]] | ||
[[Category: pentapeptide repeat protein]] | [[Category: pentapeptide repeat protein]] | ||
| Line 35: | Line 36: | ||
[[Category: toxin]] | [[Category: toxin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:54:35 2008'' |
Revision as of 00:54, 31 March 2008
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| , resolution 1.50Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Related: | 2J8I
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF THE FUSION OF NP275 AND NP276, PENTAPEPTIDE REPEAT PROTEINS FROM NOSTOC PUNCTIFORME
Overview
The Nostoc punctiforme genes Np275 and Np276 are two adjacently encoded proteins of 98 and 75 amino acids in length and exhibit sequences composed of tandem pentapeptide repeats. The structures of Np275 and a fusion of Np275 and Np276 were determined to 2.1 and 1.5 A, respectively. The two Nostoc proteins fold as highly symmetric right-handed quadrilateral beta-helices similar to the mycobacterial protein MfpA implicated in fluoroquinolone resistance and DNA gyrase inhibition. The sequence composition of the intervening coding region and the ability to express a fused protein by removing the stop codon for Np275 suggests Np275 and Np276 were recently part of a larger ancestral pentapeptide repeat protein.
About this Structure
2J8K is a Single protein structure of sequence from Nostoc punctiforme. Full crystallographic information is available from OCA.
Reference
Structural characterization of the fusion of two pentapeptide repeat proteins, Np275 and Np276, from Nostoc punctiforme: resurrection of an ancestral protein., Vetting MW, Hegde SS, Hazleton KZ, Blanchard JS, Protein Sci. 2007 Apr;16(4):755-60. PMID:17384236
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