6gct
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==cryo-EM structure of the human neutral amino acid transporter ASCT2== | |
| - | + | <StructureSection load='6gct' size='340' side='right' caption='[[6gct]], [[Resolution|resolution]] 3.85Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6gct]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GCT FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLN:GLUTAMINE'>GLN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gct OCA], [http://pdbe.org/6gct PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gct RCSB], [http://www.ebi.ac.uk/pdbsum/6gct PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gct ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AAAT_HUMAN AAAT_HUMAN]] Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids (PubMed:8702519). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904).<ref>PMID:10708449</ref> <ref>PMID:23492904</ref> <ref>PMID:8702519</ref> (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114.<ref>PMID:10051606</ref> <ref>PMID:10196349</ref> (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus.<ref>PMID:10196349</ref> (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses.<ref>PMID:10196349</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Garaeva, A A]] | ||
| + | [[Category: Gati, C]] | ||
| + | [[Category: Guskov, A]] | ||
| + | [[Category: Oostergetel, G T]] | ||
| + | [[Category: Paulino, C]] | ||
| + | [[Category: Slotboom, D J]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Neutral amino acid transporter]] | ||
Revision as of 07:44, 14 June 2018
cryo-EM structure of the human neutral amino acid transporter ASCT2
| |||||||||||
