2jh3
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 2jh3 |SIZE=350|CAPTION= <scene name='initialview01'>2jh3</scene>, resolution 1.90Å | |PDB= 2jh3 |SIZE=350|CAPTION= <scene name='initialview01'>2jh3</scene>, resolution 1.90Å | ||
|SITE= <scene name='pdbsite=AC1:Sf4+Binding+Site+For+Chain+D'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:Sf4+Binding+Site+For+Chain+D'>AC1</scene> | ||
| - | |LIGAND= <scene name='pdbligand=SF4:IRON/SULFUR CLUSTER'>SF4</scene> | + | |LIGAND= <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jh3 OCA], [http://www.ebi.ac.uk/pdbsum/2jh3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jh3 RCSB]</span> | ||
}} | }} | ||
| Line 24: | Line 27: | ||
[[Category: Leiros, H K.S.]] | [[Category: Leiros, H K.S.]] | ||
[[Category: Mcsweeney, S M.]] | [[Category: Mcsweeney, S M.]] | ||
| - | [[Category: SF4]] | ||
[[Category: 4fe-4s iron-sulphur cluster]] | [[Category: 4fe-4s iron-sulphur cluster]] | ||
[[Category: cbix]] | [[Category: cbix]] | ||
| Line 32: | Line 34: | ||
[[Category: structural genomic]] | [[Category: structural genomic]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:58:07 2008'' |
Revision as of 00:58, 31 March 2008
| |||||||
| , resolution 1.90Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THE CRYSTAL STRUCTURE OF DR2241 FROM DEINOCOCCUS RADIODURANS AT 1.9 A RESOLUTION REVEALS A MULTI-DOMAIN PROTEIN WITH STRUCTURAL SIMILARITY TO CHELATASES BUT ALSO WITH TWO ADDITIONAL NOVEL DOMAINS
Overview
A unique family of proteins have been identified in the Deinococcus genus with an N-terminal cobalamin (vitamin B(12)) chelatase domain denoted CbiX and an additional unique C-terminal domain with unknown function. Here we report the first crystal structure from this new family of proteins with the structure of Deinococcus radiodurans protein DR2241. The structure reveals a multi-domain protein where domains A (residues 1-132) has the same fold as the small CbiX (CbiX(S)), domains A and B (residues 1-272) follow the chelatase super-family fold and the two additional unique domains C and D have no structural homologues. Domain D harbours the sequence motifs CxxC and CxxxC, in which DR2241 gives the first evidence that these motifs bind a [4Fe-4S] iron-sulphur cluster. In solution there are indications of multimeric forms, and in the crystallographic asymmetric unit a tetramer is found where domains C and D are involved in stabilising the tetrameric assembly.
About this Structure
2JH3 is a Single protein structure of sequence from Deinococcus radiodurans. Full crystallographic information is available from OCA.
Reference
The crystal structure of DR2241 from Deinococcus radiodurans at 1.9 A resolution reveals a multi-domain protein with structural similarity to chelatases but also with two additional novel domains., Leiros HK, McSweeney SM, J Struct Biol. 2007 Jul;159(1):92-102. Epub 2007 Mar 12. PMID:17448684
Page seeded by OCA on Mon Mar 31 03:58:07 2008
