5xr9
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Human Hsp90 with FS6== | |
| - | + | <StructureSection load='5xr9' size='340' side='right' caption='[[5xr9]], [[Resolution|resolution]] 1.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5xr9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XR9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8CU:N-[3-[5-bromanyl-2,4-bis(oxidanyl)phenyl]-4-(4-methoxyphenyl)-1,2-oxazol-5-yl]ethanamide'>8CU</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xr9 OCA], [http://pdbe.org/5xr9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xr9 RCSB], [http://www.ebi.ac.uk/pdbsum/5xr9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xr9 ProSAT]</span></td></tr> |
| - | [[Category: He, J | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: He, J H]] | ||
[[Category: Li, J]] | [[Category: Li, J]] | ||
| + | [[Category: Shi, F]] | ||
[[Category: Xiong, B]] | [[Category: Xiong, B]] | ||
| - | [[Category: | + | [[Category: Chaperone]] |
| + | [[Category: Complex]] | ||
| + | [[Category: Heat shock protein hsp 90]] | ||
| + | [[Category: Inhibitor]] | ||
Revision as of 05:42, 20 June 2018
Crystal structure of Human Hsp90 with FS6
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Categories: He, J H | Li, J | Shi, F | Xiong, B | Chaperone | Complex | Heat shock protein hsp 90 | Inhibitor
