6bwq
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==LarC2, the C-terminal domain of a cyclometallase involved in the synthesis of the NPN cofactor of lactate racemase, in complex with MnCTP== | |
| - | + | <StructureSection load='6bwq' size='340' side='right' caption='[[6bwq]], [[Resolution|resolution]] 1.85Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6bwq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BWQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BWQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bwq OCA], [http://pdbe.org/6bwq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bwq RCSB], [http://www.ebi.ac.uk/pdbsum/6bwq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bwq ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LARC_LACPL LARC_LACPL]] Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is required for the activation of the lactate racemase LarA. May also be involved in the activation of other nickel-pincer cofactor-dependent enzymes.<ref>PMID:24710389</ref> <ref>PMID:27114550</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Fellner, M]] | ||
| + | [[Category: Hausinger, R P]] | ||
| + | [[Category: Hu, J]] | ||
| + | [[Category: Ctp]] | ||
| + | [[Category: Hexamer]] | ||
| + | [[Category: Lactate]] | ||
| + | [[Category: Lactate racemase]] | ||
| + | [[Category: Lactate racemization]] | ||
| + | [[Category: Lar]] | ||
| + | [[Category: Larc]] | ||
| + | [[Category: Metal binding protein]] | ||
| + | [[Category: Nickel]] | ||
| + | [[Category: Nickel transferase]] | ||
| + | [[Category: Trimer]] | ||
Revision as of 05:49, 20 June 2018
LarC2, the C-terminal domain of a cyclometallase involved in the synthesis of the NPN cofactor of lactate racemase, in complex with MnCTP
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Categories: Fellner, M | Hausinger, R P | Hu, J | Ctp | Hexamer | Lactate | Lactate racemase | Lactate racemization | Lar | Larc | Metal binding protein | Nickel | Nickel transferase | Trimer
