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6d9h
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist== | |
| - | + | <StructureSection load='6d9h' size='340' side='right' caption='[[6d9h]], [[Resolution|resolution]] 3.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6d9h]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D9H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D9H FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d9h OCA], [http://pdbe.org/6d9h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d9h RCSB], [http://www.ebi.ac.uk/pdbsum/6d9h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d9h ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | + | == Function == | |
| - | + | [[http://www.uniprot.org/uniprot/ACM4_HUMAN ACM4_HUMAN]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase. [[http://www.uniprot.org/uniprot/GNAI2_HUMAN GNAI2_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.<ref>PMID:17635935</ref> Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool.<ref>PMID:17550964</ref> [[http://www.uniprot.org/uniprot/GBG2_HUMAN GBG2_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). [[http://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref> | |
| - | [[ | + | == References == |
| - | [[ | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Baltos, J]] | ||
[[Category: Baumeister, W]] | [[Category: Baumeister, W]] | ||
| - | [[Category: Wootten, D]] | ||
| - | [[Category: Thal, D.M]] | ||
[[Category: Christopoulos, A]] | [[Category: Christopoulos, A]] | ||
| + | [[Category: Danev, R]] | ||
| + | [[Category: Draper-Joyce, C J]] | ||
| + | [[Category: Furness, S G.B]] | ||
[[Category: Glukhova, A]] | [[Category: Glukhova, A]] | ||
| - | [[Category: Draper-Joyce, C.J]] | ||
[[Category: Khoshouei, M]] | [[Category: Khoshouei, M]] | ||
| - | [[Category: | + | [[Category: Liang, Y L]] |
| - | [[Category: | + | [[Category: May, L T]] |
| - | [[Category: | + | [[Category: Nguyen, A T.N]] |
| + | [[Category: Plitzko, J M]] | ||
| + | [[Category: Sexton, P]] | ||
| + | [[Category: Thal, D M]] | ||
| + | [[Category: Venugopal, H]] | ||
| + | [[Category: Wootten, D]] | ||
| + | [[Category: Active-state g protein-coupled receptor]] | ||
| + | [[Category: Adenosine a1 receptor]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 05:53, 20 June 2018
Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist
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Categories: Baltos, J | Baumeister, W | Christopoulos, A | Danev, R | Draper-Joyce, C J | Furness, S G.B | Glukhova, A | Khoshouei, M | Liang, Y L | May, L T | Nguyen, A T.N | Plitzko, J M | Sexton, P | Thal, D M | Venugopal, H | Wootten, D | Active-state g protein-coupled receptor | Adenosine a1 receptor | Membrane protein | Signaling protein
