6g79

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'''Unreleased structure'''
 
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The entry 6g79 is ON HOLD until Paper Publication
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==Coupling specificity of heterotrimeric Go to the serotonin 5-HT1B receptor==
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<StructureSection load='6g79' size='340' side='right' caption='[[6g79]], [[Resolution|resolution]] 3.78&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6g79]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G79 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G79 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EP5:2-[5-[2-[4-(4-cyanophenyl)piperazin-1-yl]-2-oxidanylidene-ethoxy]-1~{H}-indol-3-yl]ethylazanium'>EP5</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g79 OCA], [http://pdbe.org/6g79 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g79 RCSB], [http://www.ebi.ac.uk/pdbsum/6g79 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g79 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/GNAO_HUMAN GNAO_HUMAN]] Early infantile epileptic encephalopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/5HT1B_HUMAN 5HT1B_HUMAN]] This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. [[http://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref> [[http://www.uniprot.org/uniprot/GNAO_HUMAN GNAO_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. [[http://www.uniprot.org/uniprot/GBG2_HUMAN GBG2_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Edwards, P]]
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[[Category: Garcia-Nafria, J]]
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[[Category: Nehme, R]]
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[[Category: Tate, C G]]
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[[Category: 5-ht1b]]
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[[Category: G-protein coupled receptor]]
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[[Category: Membrane protein]]
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[[Category: Mini-go]]
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[[Category: Serotonin]]

Revision as of 05:55, 20 June 2018

Coupling specificity of heterotrimeric Go to the serotonin 5-HT1B receptor

6g79, resolution 3.78Å

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