5w5x

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(Difference between revisions)

Revision as of 05:27, 27 June 2018

Crystal structure of BAXP168G in complex with an activating antibody

Structural highlights

5w5x is a 3 chain structure with sequence from [1] and Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
NonStd Res:
Related:	5w5z, 5w60, 5w61, 5w62, 5w63
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[BAX_HUMAN] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.^[1] ^[2] ^[3] ^[4] ^[5] ^[6]

References

↑ Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 1993 Aug 27;74(4):609-19. PMID:8358790
↑ Schmitt E, Paquet C, Beauchemin M, Dever-Bertrand J, Bertrand R. Characterization of Bax-sigma, a cell death-inducing isoform of Bax. Biochem Biophys Res Commun. 2000 Apr 21;270(3):868-79. PMID:10772918 doi:http://dx.doi.org/10.1006/bbrc.2000.2537
↑ Chittenden T, Flemington C, Houghton AB, Ebb RG, Gallo GJ, Elangovan B, Chinnadurai G, Lutz RJ. A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. EMBO J. 1995 Nov 15;14(22):5589-96. PMID:8521816
↑ Zhang H, Kim JK, Edwards CA, Xu Z, Taichman R, Wang CY. Clusterin inhibits apoptosis by interacting with activated Bax. Nat Cell Biol. 2005 Sep;7(9):909-15. Epub 2005 Aug 21. PMID:16113678 doi:http://dx.doi.org/10.1038/ncb1291
↑ Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng EH, Tjandra N, Walensky LD. BAX activation is initiated at a novel interaction site. Nature. 2008 Oct 23;455(7216):1076-81. PMID:18948948 doi:10.1038/nature07396
↑ Czabotar PE, Lee EF, Thompson GV, Wardak AZ, Fairlie WD, Colman PM. Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis. J Biol Chem. 2011 Mar 4;286(9):7123-31. Epub 2011 Jan 3. PMID:21199865 doi:10.1074/jbc.M110.161281

1 Structural highlights
2 Function
3 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5w5x"

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5w5x is ON HOLD  until Paper Publication
+==Crystal structure of BAXP168G in complex with an activating antibody==
+<StructureSection load='5w5x' size='340' side='right' caption='[[5w5x]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-Authors: Robin, A.Y., Colman, P.M., Czabotar, P.E.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5w5x]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W5X FirstGlance]. <br>
-Description: Crystal structure of BAXP168G in complex with an activating antibody
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-[[Category: Robin, A.Y]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5w5z|5w5z]], [[5w60|5w60]], [[5w61|5w61]], [[5w62|5w62]], [[5w63|5w63]]</td></tr>
-[[Category: Czabotar, P.E]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w5x OCA], [http://pdbe.org/5w5x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w5x RCSB], [http://www.ebi.ac.uk/pdbsum/5w5x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w5x ProSAT]</span></td></tr>
-[[Category: Colman, P.M]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN]] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Rattus norvegicus]]
+[[Category: Colman, P M]]
+[[Category: Czabotar, P E]]
+[[Category: Robin, A Y]]
+[[Category: Apoptosis]]
+[[Category: Apoptosis-immune system complex]]
+[[Category: Bax activation]]
+[[Category: Fabss']]
+[[Category: Unfolding]]

5w5x

From Proteopedia

Revision as of 05:27, 27 June 2018

Crystal structure of BAXP168G in complex with an activating antibody

Structural highlights

Function

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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