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5w5z

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'''Unreleased structure'''
 
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The entry 5w5z is ON HOLD until Paper Publication
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==Crystal structure of BAXP168G in complex with an activating antibody at high resolution==
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<StructureSection load='5w5z' size='340' side='right' caption='[[5w5z]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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Authors: Robin, A.Y., Colman, P.M., Czabotar, P.E.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5w5z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W5Z FirstGlance]. <br>
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Description: Crystal structure of BAXP168G in complex with an activating antibody at high resolution
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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[[Category: Robin, A.Y]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w5z OCA], [http://pdbe.org/5w5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w5z RCSB], [http://www.ebi.ac.uk/pdbsum/5w5z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w5z ProSAT]</span></td></tr>
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[[Category: Czabotar, P.E]]
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</table>
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[[Category: Colman, P.M]]
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== Function ==
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[[http://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN]] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Rattus norvegicus]]
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[[Category: Colman, P M]]
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[[Category: Czabotar, P E]]
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[[Category: Robin, A Y]]
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[[Category: Apoptosis]]
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[[Category: Bax activation]]
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[[Category: Fab]]
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[[Category: Unfolding]]

Revision as of 05:27, 27 June 2018

Crystal structure of BAXP168G in complex with an activating antibody at high resolution

5w5z, resolution 2.00Å

Drag the structure with the mouse to rotate

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