5w62

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m (Protected "5w62" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5w62 is ON HOLD until Paper Publication
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==Crystal structure of mouse BAX monomer==
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<StructureSection load='5w62' size='340' side='right' caption='[[5w62]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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Authors: Robin, A.Y., Colman, P.M., Czabotar, P.E., Luo, C.S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5w62]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W62 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W62 FirstGlance]. <br>
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Description: Crystal structure of mouse BAX monomer
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5w5x|5w5x]], [[5w5z|5w5z]], [[5w60|5w60]], [[5w61|5w61]], [[5w63|5w63]]</td></tr>
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[[Category: Robin, A.Y]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w62 OCA], [http://pdbe.org/5w62 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w62 RCSB], [http://www.ebi.ac.uk/pdbsum/5w62 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w62 ProSAT]</span></td></tr>
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[[Category: Luo, C.S]]
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</table>
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[[Category: Czabotar, P.E]]
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== Function ==
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[[Category: Colman, P.M]]
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[[http://www.uniprot.org/uniprot/BAX_MOUSE BAX_MOUSE]] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. BAX deficiency leads to lymphoid hyperplasia and male sterility, because of the cessation of sperm production.<ref>PMID:8358790</ref> <ref>PMID:21060336</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Colman, P M]]
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[[Category: Czabotar, P E]]
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[[Category: Luo, C S]]
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[[Category: Robin, A Y]]
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[[Category: Apoptosis]]
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[[Category: Bax]]
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[[Category: Monomer]]
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[[Category: Mouse]]

Revision as of 05:27, 27 June 2018

Crystal structure of mouse BAX monomer

5w62, resolution 2.20Å

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