6cit

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'''Unreleased structure'''
 
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The entry 6cit is ON HOLD until Paper Publication
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==Crystal Structure of MVM NS2 NES Peptide in complex with CRM1-Ran-RanBP1==
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<StructureSection load='6cit' size='340' side='right' caption='[[6cit]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
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Authors: Fung, H.Y.J., Chook, Y.M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6cit]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CIT FirstGlance]. <br>
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Description: Crystal Structure of MVM NS2 NES Peptide in complex with CRM1-Ran-RanBP1
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cit OCA], [http://pdbe.org/6cit PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cit RCSB], [http://www.ebi.ac.uk/pdbsum/6cit PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cit ProSAT]</span></td></tr>
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[[Category: Fung, H.Y.J]]
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</table>
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[[Category: Chook, Y.M]]
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== Function ==
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[[http://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> [[http://www.uniprot.org/uniprot/XPO1_YEAST XPO1_YEAST]] Receptor for the leucine-rich nuclear export signal (NES). [[http://www.uniprot.org/uniprot/YRB1_YEAST YRB1_YEAST]] Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1 and GSP2.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Chook, Y M]]
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[[Category: Fung, H Y.J]]
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[[Category: Crm1]]
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[[Category: Exportin-1]]
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[[Category: Karyopherin]]
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[[Category: Mvm]]
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[[Category: Ne]]
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[[Category: Nuclear export]]
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[[Category: Protein transport]]
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[[Category: Xpo1]]

Revision as of 05:36, 27 June 2018

Crystal Structure of MVM NS2 NES Peptide in complex with CRM1-Ran-RanBP1

6cit, resolution 2.03Å

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