6fc2
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the eIF4E-Eap1p complex from Saccharomyces cerevisiae== | |
| - | + | <StructureSection load='6fc2' size='340' side='right' caption='[[6fc2]], [[Resolution|resolution]] 1.92Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6fc2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FC2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FC2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fc2 OCA], [http://pdbe.org/6fc2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fc2 RCSB], [http://www.ebi.ac.uk/pdbsum/6fc2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fc2 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IF4E_YEAST IF4E_YEAST]] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. [[http://www.uniprot.org/uniprot/EAP1_YEAST EAP1_YEAST]] Can regulate translation through binding to eIF4E. Competes with eIF4G and p20 for binding to eIF4E in vivo and inhibits cap-dependent translation in vitro. Plays a role in cell growth and is implicated in the TOR signaling cascade. Functions independently of eIF4E to maintain genetic stability and to attenuate GCN4 translation upon TOR inactivation.<ref>PMID:10848587</ref> <ref>PMID:11114520</ref> <ref>PMID:15848184</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gruener, S]] | ||
| + | [[Category: Valkov, E]] | ||
| + | [[Category: Gene expression translation translational control 4e-binding protein]] | ||
| + | [[Category: Translation]] | ||
Revision as of 05:40, 27 June 2018
Crystal structure of the eIF4E-Eap1p complex from Saccharomyces cerevisiae
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