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5y33
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of alginate lyase from Flavobacterium sp. UMI-01 reveals polymannuronate specificity== | |
| + | <StructureSection load='5y33' size='340' side='right' caption='[[5y33]], [[Resolution|resolution]] 1.54Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5y33]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y33 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y33 FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y33 OCA], [http://pdbe.org/5y33 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y33 RCSB], [http://www.ebi.ac.uk/pdbsum/5y33 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y33 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | FlAlyA is an endolytic enzyme with a preference for polymannuronate. The crystal structure and mutagenesis studies elucidated that the structural variations at outer uronate-binding subsites +2, +3 and -2 control the enzymatic properties of PL-7 family enzymes. Lys158 mutations changed the pH dependency and enhanced the production of mono- and disaccharides. | ||
| - | + | Structural basis for controlling the enzymatic properties of polymannuronate preferred alginate lyase FlAlyA from the PL-7 family.,Qin HM, Miyakawa T, Inoue A, Nishiyama R, Nakamura A, Asano A, Ojima T, Tanokura M Chem Commun (Camb). 2018 Jan 11;54(5):555-558. doi: 10.1039/c7cc06523j. PMID:29292806<ref>PMID:29292806</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 5y33" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Miyakawa, T]] | [[Category: Miyakawa, T]] | ||
[[Category: Nakamura, A]] | [[Category: Nakamura, A]] | ||
| + | [[Category: Qin, H M]] | ||
| + | [[Category: Tanokura, M]] | ||
| + | [[Category: Alginate lyase]] | ||
| + | [[Category: B-elimination reaction]] | ||
| + | [[Category: B-jelly roll fold]] | ||
| + | [[Category: Endolytic enzyme]] | ||
| + | [[Category: Structural protein]] | ||
Revision as of 07:08, 4 July 2018
Crystal structure of alginate lyase from Flavobacterium sp. UMI-01 reveals polymannuronate specificity
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