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2nqc
From Proteopedia
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|PDB= 2nqc |SIZE=350|CAPTION= <scene name='initialview01'>2nqc</scene>, resolution 2.050Å | |PDB= 2nqc |SIZE=350|CAPTION= <scene name='initialview01'>2nqc</scene>, resolution 2.050Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqc OCA], [http://www.ebi.ac.uk/pdbsum/2nqc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2nqc RCSB]</span> | ||
}} | }} | ||
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[[Category: Svergun, D.]] | [[Category: Svergun, D.]] | ||
[[Category: Ylanne, J.]] | [[Category: Ylanne, J.]] | ||
| - | [[Category: GOL]] | ||
| - | [[Category: IMD]] | ||
| - | [[Category: NI]] | ||
[[Category: filamin]] | [[Category: filamin]] | ||
[[Category: immune system]] | [[Category: immune system]] | ||
| Line 40: | Line 40: | ||
[[Category: metal binding]] | [[Category: metal binding]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:06:49 2008'' |
Revision as of 01:06, 31 March 2008
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| , resolution 2.050Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of ig-like domain 23 from human filamin C
Overview
Filamin C is a dimeric, actin-binding protein involved in organization of cortical cytoskeleton and of the sarcomere. We performed crystallographic, small-angle X-ray scattering and analytical ultracentrifugation experiments on the constructs containing carboxy-terminal domains of the protein (domains 23-24 and 19-21). The crystal structure of domain 23 of filamin C showed that the protein adopts the expected immunoglobulin (Ig)-like fold. Small-angle X-ray scattering experiments performed on filamin C tandem Ig-like domains 23 and 24 reveal a dimer that is formed by domain 24 and that domain 23 has little interactions with itself or with domain 24, while the analytical ultracentrifugation experiments showed that the filamin C domains 19-21 form elongated monomers in diluted solutions.
About this Structure
2NQC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of human filamin C domain 23 and small angle scattering model for filamin C 23-24 dimer., Sjekloca L, Pudas R, Sjoblom B, Konarev P, Carugo O, Rybin V, Kiema TR, Svergun D, Ylanne J, Djinovic Carugo K, J Mol Biol. 2007 May 11;368(4):1011-23. Epub 2007 Feb 20. PMID:17379241
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