5xy9

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m (Protected "5xy9" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5xy9 is ON HOLD until Paper Publication
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==Structure of the MST4 and 14-3-3 complex==
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<StructureSection load='5xy9' size='340' side='right' caption='[[5xy9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5xy9]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XY9 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xy9 OCA], [http://pdbe.org/5xy9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xy9 RCSB], [http://www.ebi.ac.uk/pdbsum/5xy9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xy9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/1433Z_HUMAN 1433Z_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.<ref>PMID:9360956</ref> <ref>PMID:14578935</ref> <ref>PMID:15071501</ref> <ref>PMID:15644438</ref> <ref>PMID:16376338</ref> [[http://www.uniprot.org/uniprot/STK26_HUMAN STK26_HUMAN]] Mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006).<ref>PMID:11641781</ref> <ref>PMID:17360971</ref> <ref>PMID:27807006</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Shi, Z B]]
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[[Category: Zhou, Z C]]
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[[Category: Kinase]]
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[[Category: Melanoma metastasis]]
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[[Category: Phosphorylation]]
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[[Category: Protein binding]]
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[[Category: Protein complex]]
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[[Category: Signaling protein]]

Revision as of 05:37, 11 July 2018

Structure of the MST4 and 14-3-3 complex

5xy9, resolution 2.30Å

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