6dt0
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of a mitochondrial calcium uniporter== | |
| + | <StructureSection load='6dt0' size='340' side='right' caption='[[6dt0]], [[Resolution|resolution]] 3.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6dt0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DT0 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dt0 OCA], [http://pdbe.org/6dt0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dt0 RCSB], [http://www.ebi.ac.uk/pdbsum/6dt0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dt0 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Calcium transport plays an important role in regulating mitochondrial physiology and pathophysiology. The mitochondrial calcium uniporter (MCU) is a calcium-selective ion channel that is the primary mediator for calcium uptake into the mitochondrial matrix. Here we present the cryo-electron microscopy structure of the full-length MCU from Neurospora crassa to an overall resolution of ~3.7 A. Our structure reveals a tetrameric architecture, with the soluble and transmembrane domains adopting different symmetric arrangements within the channel. The conserved W-D-Phi-Phi-E-P-V-T-Y sequence motif of MCU pore forms a selectivity filter comprising two acidic rings separated by one helical turn along the central axis of the channel pore. The structure combined with mutagenesis gives insight into the basis of calcium recognition. | ||
| - | + | Cryo-EM structure of a mitochondrial calcium uniporter.,Yoo J, Wu M, Yin Y, Herzik MA Jr, Lander GC, Lee SY Science. 2018 Jun 28. pii: science.aar4056. doi: 10.1126/science.aar4056. PMID:29954988<ref>PMID:29954988</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6dt0" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Herzik, M A.J]] | ||
| + | [[Category: Lander, G C]] | ||
| + | [[Category: Lee, S Y]] | ||
| + | [[Category: Wu, M]] | ||
| + | [[Category: Yin, Y]] | ||
| + | [[Category: Yoo, J]] | ||
| + | [[Category: Calcium uptake]] | ||
| + | [[Category: Calcium-selective ion channel]] | ||
| + | [[Category: Mitochondrial calcium uniporter]] | ||
| + | [[Category: Transport protein]] | ||
| + | [[Category: Uniporter]] | ||
Revision as of 05:44, 11 July 2018
Cryo-EM structure of a mitochondrial calcium uniporter
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