2nyr

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|PDB= 2nyr |SIZE=350|CAPTION= <scene name='initialview01'>2nyr</scene>, resolution 2.06&Aring;
|PDB= 2nyr |SIZE=350|CAPTION= <scene name='initialview01'>2nyr</scene>, resolution 2.06&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=SVR:8,8&#39;-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFONIC+ACID'>SVR</scene> and <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
+
|LIGAND= <scene name='pdbligand=SVR:8,8&#39;-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFONIC+ACID'>SVR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= SIRT5, SIR2L5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|GENE= SIRT5, SIR2L5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
 +
|DOMAIN=
 +
|RELATEDENTRY=
 +
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nyr OCA], [http://www.ebi.ac.uk/pdbsum/2nyr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2nyr RCSB]</span>
}}
}}
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[[Category: Sundstrom, M.]]
[[Category: Sundstrom, M.]]
[[Category: Weigelt, J.]]
[[Category: Weigelt, J.]]
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[[Category: SVR]]
 
-
[[Category: ZN]]
 
[[Category: histone deacetylase]]
[[Category: histone deacetylase]]
[[Category: hydrolase]]
[[Category: hydrolase]]
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[[Category: structural genomics consortium]]
[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 15:29:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:10:23 2008''

Revision as of 01:10, 31 March 2008

Image:2nyr.gif


PDB ID 2nyr

Drag the structure with the mouse to rotate
, resolution 2.06Å
Ligands: ,
Gene: SIRT5, SIR2L5 (Homo sapiens)
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of Human Sirtuin Homolog 5 in Complex with Suramin


Overview

Sirtuins are NAD(+)-dependent protein deacetylases and are emerging as molecular targets for the development of pharmaceuticals to treat human metabolic and neurological diseases and cancer. To date, several sirtuin inhibitors and activators have been identified, but the structural mechanisms of how these compounds modulate sirtuin activity have not yet been determined. We identified suramin as a compound that binds to human SIRT5 and showed that it inhibits SIRT5 NAD(+)-dependent deacetylase activity with an IC(50) value of 22 microM. To provide insights into how sirtuin function is altered by inhibitors, we determined two crystal structures of SIRT5, one in complex with ADP-ribose, the other bound to suramin. Our structural studies provide a view of a synthetic inhibitory compound in a sirtuin active site revealing that suramin binds into the NAD(+), the product, and the substrate-binding site. Finally, our structures may enable the rational design of more potent inhibitors.

About this Structure

2NYR is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 2FZQ. Full crystallographic information is available from OCA.

Reference

Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin., Schuetz A, Min J, Antoshenko T, Wang CL, Allali-Hassani A, Dong A, Loppnau P, Vedadi M, Bochkarev A, Sternglanz R, Plotnikov AN, Structure. 2007 Mar;15(3):377-89. PMID:17355872

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