5y0d
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the human nucleosome containing the H2B E76K mutant== | |
| - | + | <StructureSection load='5y0d' size='340' side='right' caption='[[5y0d]], [[Resolution|resolution]] 1.99Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5y0d]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y0D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y0D FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y0d OCA], [http://pdbe.org/5y0d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y0d RCSB], [http://www.ebi.ac.uk/pdbsum/5y0d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y0d ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arimura, Y]] | ||
| + | [[Category: Fujita, R]] | ||
| + | [[Category: Kurumizaka, H]] | ||
| + | [[Category: Noda, M]] | ||
| + | [[Category: Chromatin formation]] | ||
| + | [[Category: Dna binding]] | ||
| + | [[Category: Dna binding protein-dna complex]] | ||
| + | [[Category: Histone fold]] | ||
| + | [[Category: Nucleosome]] | ||
| + | [[Category: Nucleus]] | ||
Revision as of 07:29, 18 July 2018
Crystal Structure of the human nucleosome containing the H2B E76K mutant
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