5yy4

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'''Unreleased structure'''
 
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The entry 5yy4 is ON HOLD until Paper Publication
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==Crystal structure of the scFv antibody 4B08 with sulfated epitope peptide==
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<StructureSection load='5yy4' size='340' side='right' caption='[[5yy4]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
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Authors: Caaveiro, J.M.M., Miyanabe, K., Tsumoto, K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5yy4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YY4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YY4 FirstGlance]. <br>
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Description: Crystal structure of the scFv antibody 4B08 with sulfated epitope peptide
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yy4 OCA], [http://pdbe.org/5yy4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yy4 RCSB], [http://www.ebi.ac.uk/pdbsum/5yy4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yy4 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN]] Genetic variation in CCR5 is associated with susceptibility to diabetes mellitus insulin-dependent type 22 (IDDM22) [MIM:[http://omim.org/entry/612522 612522]]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:19073967</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN]] Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.<ref>PMID:8639485</ref> <ref>PMID:8663314</ref> <ref>PMID:8699119</ref> <ref>PMID:8649511</ref> <ref>PMID:8649512</ref> <ref>PMID:11323418</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Caaveiro, J M.M]]
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[[Category: Miyanabe, K]]
[[Category: Tsumoto, K]]
[[Category: Tsumoto, K]]
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[[Category: Caaveiro, J.M.M]]
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[[Category: Antibody]]
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[[Category: Miyanabe, K]]
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[[Category: Biomolecular recognition]]
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[[Category: Immune system]]
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[[Category: Md simulation]]
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[[Category: Thermodynamic]]

Revision as of 07:31, 18 July 2018

Crystal structure of the scFv antibody 4B08 with sulfated epitope peptide

5yy4, resolution 1.59Å

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