6bec
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of VACV D13 in complex with Rifabutin== | |
| - | + | <StructureSection load='6bec' size='340' side='right' caption='[[6bec]], [[Resolution|resolution]] 2.91Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6bec]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BEC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BEC FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=RBT:RIFABUTIN'>RBT</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3sam|3sam]], [[3saq|3saq]], [[6beb|6beb]], [[6bed|6bed]], [[6bee|6bee]], [[6bef|6bef]], [[6beg|6beg]], [[6bei|6bei]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bec OCA], [http://pdbe.org/6bec PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bec RCSB], [http://www.ebi.ac.uk/pdbsum/6bec PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bec ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/D13_VACCW D13_VACCW]] Scaffold protein which forms a transitory spherical honeycomb lattice providing curvature and rigidity to the convex membrane of crescent and immature virions (IV). This association occurs concomitantly with viral membrane formation. Targeted by the drug rifampicin, which prevents the formation of this lattice, and hence virus morphogenesis. In the presence of rifampicin, irregularly shaped membranes that lack the honeycomb layer accumulate around areas of electron-dense viroplasm. This layer is lost from virions during maturation from IV to mature virion (MV), through the proteolysis of A17 N-terminus. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Accurso, C]] | ||
| + | [[Category: Coulibaly, F]] | ||
| + | [[Category: Garriga, D]] | ||
| + | [[Category: Assembly]] | ||
| + | [[Category: Immature virion]] | ||
| + | [[Category: Poxvirus]] | ||
| + | [[Category: Rifampicin resistance protein]] | ||
| + | [[Category: Scaffolding protein]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 07:33, 18 July 2018
Crystal structure of VACV D13 in complex with Rifabutin
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