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6ct9
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the human cGAS-DNA complex== | |
| - | + | <StructureSection load='6ct9' size='340' side='right' caption='[[6ct9]], [[Resolution|resolution]] 2.26Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ct9]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CT9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CT9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic_GMP-AMP_synthase Cyclic GMP-AMP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.86 2.7.7.86] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ct9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ct9 OCA], [http://pdbe.org/6ct9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ct9 RCSB], [http://www.ebi.ac.uk/pdbsum/6ct9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ct9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cyclic GMP-AMP synthase]] | ||
| + | [[Category: Kranzusch, P J]] | ||
| + | [[Category: Mann, C C.de Oliveira]] | ||
| + | [[Category: Mekalanos, J J]] | ||
| + | [[Category: Morehouse, B R]] | ||
| + | [[Category: Whiteley, A T]] | ||
| + | [[Category: Zhou, W]] | ||
| + | [[Category: Cga]] | ||
| + | [[Category: Innate immunity]] | ||
| + | [[Category: Sting]] | ||
| + | [[Category: Transferase]] | ||
| + | [[Category: Transferase-dna complex]] | ||
Revision as of 07:36, 18 July 2018
Structure of the human cGAS-DNA complex
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