2o3m
From Proteopedia
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|PDB= 2o3m |SIZE=350|CAPTION= <scene name='initialview01'>2o3m</scene> | |PDB= 2o3m |SIZE=350|CAPTION= <scene name='initialview01'>2o3m</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2a5p|2A5P]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o3m OCA], [http://www.ebi.ac.uk/pdbsum/2o3m PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2o3m RCSB]</span> | ||
}} | }} | ||
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[[Category: Patel, D J.]] | [[Category: Patel, D J.]] | ||
[[Category: Phan, A T.]] | [[Category: Phan, A T.]] | ||
| - | [[Category: | + | [[Category: edgewise]] |
| - | [[Category: g-tetrad;parallel g-quadruplex | + | [[Category: g-tetrad;parallel g-quadruplex]] |
| - | [[Category: single-residue cha reversal]] | + | [[Category: single-residue cha reversal,5-nucleotide snap-back loops;broken strand topolog]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:12:15 2008'' |
Revision as of 01:12, 31 March 2008
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| Ligands: | , , , | ||||||
| Related: | 2A5P
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Monomeric G-DNA tetraplex from human C-kit promoter
Overview
The c-kit oncogene is an important target in the treatment of gastrointestinal tumors. A potential approach to inhibition of the expression of this gene involves selective stabilization of G-quadruplex structures that may be induced to form in the c-kit promoter region. Here we report on the structure of an unprecedented intramolecular G-quadruplex formed by a G-rich sequence in the c-kit promoter in K+ solution. The structure represents a new folding topology with several unique features. Most strikingly, an isolated guanine is involved in G-tetrad core formation, despite the presence of four three-guanine tracts. There are four loops: two single-residue double-chain-reversal loops, a two-residue loop, and a five-residue stem-loop, which contain base-pairing alignments. This unique structural scaffold provides a highly specific platform for the future design of ligands specifically targeted to the promoter DNA of c-kit.
About this Structure
2O3M is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter., Phan AT, Kuryavyi V, Burge S, Neidle S, Patel DJ, J Am Chem Soc. 2007 Apr 11;129(14):4386-92. Epub 2007 Mar 16. PMID:17362008
Page seeded by OCA on Mon Mar 31 04:12:15 2008
