2o7n

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 4: Line 4:
|PDB= 2o7n |SIZE=350|CAPTION= <scene name='initialview01'>2o7n</scene>, resolution 1.75&Aring;
|PDB= 2o7n |SIZE=350|CAPTION= <scene name='initialview01'>2o7n</scene>, resolution 1.75&Aring;
|SITE=
|SITE=
-
|LIGAND= <scene name='pdbligand=2O7:7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile'>2O7</scene>
+
|LIGAND= <scene name='pdbligand=2O7:7A-[(4-CYANOPHENYL)METHYL]-6-(3,5-DICHLOROPHENYL)-5-OXO-2,3,5,7A-TETRAHYDRO-1H-PYRROLO[1,2-A]PYRROLE-7-CARBONITRILE'>2O7</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= ITGAL, CD11A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|GENE= ITGAL, CD11A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
 +
|DOMAIN=
 +
|RELATEDENTRY=[[2ica|2ICA]]
 +
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o7n OCA], [http://www.ebi.ac.uk/pdbsum/2o7n PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2o7n RCSB]</span>
}}
}}
Line 23: Line 26:
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Sheriff, S.]]
[[Category: Sheriff, S.]]
-
[[Category: 2O7]]
+
[[Category: inhibitor,protein/ligand complex]]
-
[[Category: inhibitor]]
+
-
[[Category: protein/ligand complex]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:56:07 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:13:52 2008''

Revision as of 01:13, 31 March 2008

Image:2o7n.gif


PDB ID 2o7n

Drag the structure with the mouse to rotate
, resolution 1.75Å
Ligands:
Gene: ITGAL, CD11A (Homo sapiens)
Related: 2ICA


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



CD11A (LFA1) I-domain complexed with 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile


Overview

A new class of lymphocyte function-associated antigen-1 (LFA-1) antagonists is described. Elaboration of the 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold resulted in the synthesis of potent inhibitors of the LFA-1/ICAM-1 interaction. Along with the in vitro activity, we present the X-ray crystal structure of the complex of compound 9b, in a novel binding mode to the I-domain of LFA-1.

About this Structure

2O7N is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Design of LFA-1 antagonists based on a 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold., Dodd DS, Sheriff S, Chang CJ, Stetsko DK, Phillips LM, Zhang Y, Launay M, Potin D, Vaccaro W, Poss MA, McKinnon M, Barrish JC, Suchard SJ, Murali Dhar TG, Bioorg Med Chem Lett. 2007 Apr 1;17(7):1908-11. Epub 2007 Jan 24. PMID:17291752

Page seeded by OCA on Mon Mar 31 04:13:52 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2o7n"
Personal tools