Importin

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Line 38: Line 38:
**[[4xzr]] – yIPO NLS-binding domain + HEH1<br />
**[[4xzr]] – yIPO NLS-binding domain + HEH1<br />
**[[4pvz]] – yIPO NLS-binding domain + HEH2<br />
**[[4pvz]] – yIPO NLS-binding domain + HEH2<br />
-
**[[4rxh]] – IPO NLS-binding domain + SV40 large T antigen – ''Neurospora crassa''<br />
+
**[[4rxh]] – NcIPO NLS-binding domain + SV40 large T antigen – ''Neurospora crassa''<br />
 +
**[[5vqi]] – NcIPO NLS-binding domain + NIT2<br />
*''IPO-α complex with protein''
*''IPO-α complex with protein''
**[[1wa5]] – yIPO NLS-binding domain + GTPase Ran + IPO-α re-exporter<br />
**[[1wa5]] – yIPO NLS-binding domain + GTPase Ran + IPO-α re-exporter<br />
 +
**[[5t94]] – yIPO NLS-binding domain + guanine nucleotide exchange factor <br />
 +
**[[5mfm]] – yIPO NLS-binding domain + YIIIM6AII <br />
*IPO-α 1
*IPO-α 1
Line 48: Line 51:
**[[3wpt]] – hIPO NLS-binding domain - human<br />
**[[3wpt]] – hIPO NLS-binding domain - human<br />
**[[4b8j]] – rIPO <br />
**[[4b8j]] – rIPO <br />
 +
**[[6bvt]] – mIPO NLS-binding domain <br />
*''IPO-α 1 complex with NLS peptide''
*''IPO-α 1 complex with NLS peptide''
Line 68: Line 72:
**[[4b18]] – hIPO NLS-binding domain + telomerase reverse transcriptase<br />
**[[4b18]] – hIPO NLS-binding domain + telomerase reverse transcriptase<br />
**[[4wv6]] – hIPO NLS-binding domain + TFIID<br />
**[[4wv6]] – hIPO NLS-binding domain + TFIID<br />
 +
**[[6bw0]] – hIPO NLS-binding domain + Nipa virus peptide<br />
 +
**[[6bw1]] – hIPO NLS-binding domain + Hendra virus peptide<br />
 +
**[[5w41]] – mIPO NLS-binding domain + Zika virus peptide <br />
 +
**[[5v5o]], [[5v5p]] – mIPO NLS-binding domain + influenza virus peptide <br />
 +
**[[5umz]] – mIPO NLS-binding domain + TNRC6A peptide <br />
 +
**[[5u5p]], [[5u5r]] – mIPO NLS-binding domain + MLH1 peptide <br />
 +
**[[5gxw]] – mIPO NLS-binding domain + NUMA peptide <br />
 +
**[[5w4e]], [[5w4f]], [[5w4g]] – hIPO NLS-binding domain + polymerase peptide<br />
 +
**[[5h43]] – hIPO NLS-binding domain + histone acetyltransferase KAT8<br />
**[[4b8o]] – rIPO NLS-binding domain + SV40<br />
**[[4b8o]] – rIPO NLS-binding domain + SV40<br />
**[[4b8p]] – rIPO NLS-binding domain + A89<br />
**[[4b8p]] – rIPO NLS-binding domain + A89<br />
Line 116: Line 129:
*IPO-α 3
*IPO-α 3
 +
**[[6bvz]] – hIPO NLS-binding domain <br />
**[[4uae]] – hIPO NLS-binding domain + influenza RNA polymerase<br />
**[[4uae]] – hIPO NLS-binding domain + influenza RNA polymerase<br />
 +
**[[6bw9]], [[6bwa]], [[6bwb]] – hIPO NLS-binding domain + Hendra virus peptide<br />
 +
**[[6bvv]] – hIPO NLS-binding domain + Nipa virus peptide<br />
 +
**[[5xzx]] – hIPO NLS-binding domain + RAN-binding protein peptide<br />
 +
**[[5tbk]] – hIPO NLS-binding domain + regulator of chromosome condensation <br />
*IPO-α 6
*IPO-α 6
Line 157: Line 175:
**[[2z5o]] – hIPO + JKTBP peptide<br />
**[[2z5o]] – hIPO + JKTBP peptide<br />
**[[4fdd]], [[4jlq]], [[4oo6]] – hIPO + RNA binding protein peptide<br />
**[[4fdd]], [[4jlq]], [[4oo6]] – hIPO + RNA binding protein peptide<br />
 +
**[[5yvg]], [[5yvh]] – hIPO + FUS <br />
 +
**[[5vyh]], [[5vyi]] – hIPO + FUS peptide<br />
**[[4fq3]] – hIPO + FUS peptide<br />
**[[4fq3]] – hIPO + FUS peptide<br />
**[[5tqc]] – hIPO + RPL4 peptide<br />
**[[5tqc]] – hIPO + RPL4 peptide<br />
Line 171: Line 191:
**[[5h2v]] – yIPO + ubiquitin-like specific protease<br />
**[[5h2v]] – yIPO + ubiquitin-like specific protease<br />
**[[4zj7]] – yIPO + CDC14<br />
**[[4zj7]] – yIPO + CDC14<br />
 +
 +
*IPO-4B
 +
 +
**[[5xah]] – hIPO residues 668-1081 <br />
 +
**[[5xbk]] – hIPO residues 668-1081 + histone H3 peptide <br />
*IPO-12 (Transportin-3)
*IPO-12 (Transportin-3)

Revision as of 08:10, 19 July 2018

Structure of yeast importin α NLS-binding domain (grey) complex with nucleoplasmin peptide (green) (PDB code 1ee5).

Drag the structure with the mouse to rotate

3D structures of importin

Updated on 19-July-2018

References

  1. ↑ Mattaj IW, Englmeier L. Nucleocytoplasmic transport: the soluble phase. Annu Rev Biochem. 1998;67:265-306. PMID:9759490 doi:http://dx.doi.org/10.1146/annurev.biochem.67.1.265
  2. ↑ Pumroy RA, Cingolani G. Diversification of importin-alpha isoforms in cellular trafficking and disease states. Biochem J. 2015 Feb 15;466(1):13-28. doi: 10.1042/BJ20141186. PMID:25656054 doi:http://dx.doi.org/10.1042/BJ20141186

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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