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| - | == | + | == Overview == |
<Structure load='4ny4' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | <Structure load='4ny4' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | ||
| - | == | + | == Mechanism == |
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| - | == | + | == Structure and Sequence == |
| + | The gene encoding CYP3A4 is located on chromosome 7 in the human genome[6] and it has been found that there are significant variants of the protein correlating to race [7]. This finding is relevant due to the proteins altered ability to react with substrates such as testosterone [8]. | ||
| - | + | The | |
| - | == | + | Show:Asymmetric Unit Biological Assembly, QSbio confidence: Low |
| + | Export Animated Image | ||
| + | alpha helices can be seen colored in rainbow succession from the N to C terminus. The protein pocket, where the reactions are catalyzed, more specifically, the heme binding site contains twenty-two residues [5] but the main interaction is with a Cysteine at position 442, which coordinates with iron. | ||
| + | |||
| + | == Drug Metabolism == | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 02:52, 20 July 2018
Contents |
Overview
|
Mechanism
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Structure and Sequence
The gene encoding CYP3A4 is located on chromosome 7 in the human genome[6] and it has been found that there are significant variants of the protein correlating to race [7]. This finding is relevant due to the proteins altered ability to react with substrates such as testosterone [8].
The Show:Asymmetric Unit Biological Assembly, QSbio confidence: Low
Export Animated Image
alpha helices can be seen colored in rainbow succession from the N to C terminus. The protein pocket, where the reactions are catalyzed, more specifically, the heme binding site contains twenty-two residues [5] but the main interaction is with a Cysteine at position 442, which coordinates with iron.
