6e08
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of G6PD in complex with structural NADP== | |
| - | + | <StructureSection load='6e08' size='340' side='right' caption='[[6e08]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6e08]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5vfl 5vfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E08 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | |
| - | [[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucose-6-phosphate_dehydrogenase Glucose-6-phosphate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.49 1.1.1.49] </span></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e08 OCA], [http://pdbe.org/6e08 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e08 RCSB], [http://www.ebi.ac.uk/pdbsum/6e08 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e08 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/G6PD_HUMAN G6PD_HUMAN]] Defects in G6PD are the cause of chronic non-spherocytic hemolytic anemia (CNSHA) [MIM:[http://omim.org/entry/305900 305900]]. Deficiency of G6PD is associated with hemolytic anemia in two different situations. First, in areas in which malaria has been endemic, G6PD-deficiency alleles have reached high frequencies (1% to 50%) and deficient individuals, though essentially asymptomatic in the steady state, have a high risk of acute hemolytic attacks. Secondly, sporadic cases of G6PD deficiency occur at a very low frequencies, and they usually present a more severe phenotype. Several types of CNSHA are recognized. Class-I variants are associated with severe NSHA; class-II have an activity <10% of normal; class-III have an activity of 10% to 60% of normal; class-IV have near normal activity.<ref>PMID:1611091</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/G6PD_HUMAN G6PD_HUMAN]] Produces pentose sugars for nucleic acid synthesis and main producer of NADPH reducing power. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Glucose-6-phosphate dehydrogenase]] | ||
[[Category: Rahighi, S]] | [[Category: Rahighi, S]] | ||
| + | [[Category: Rosen, D Mochly]] | ||
[[Category: Wakatsuki, S]] | [[Category: Wakatsuki, S]] | ||
| + | [[Category: G6pd]] | ||
| + | [[Category: Nadp]] | ||
| + | [[Category: Oxidoreductase]] | ||
Revision as of 07:05, 25 July 2018
Crystal structure of G6PD in complex with structural NADP
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