5wi9
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of KL with an agonist Fab== | |
| - | + | <StructureSection load='5wi9' size='340' side='right' caption='[[5wi9]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5wi9]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WI9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WI9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wi9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wi9 OCA], [http://pdbe.org/5wi9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wi9 RCSB], [http://www.ebi.ac.uk/pdbsum/5wi9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wi9 ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KLOTB_HUMAN KLOTB_HUMAN]] Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Johnstone, S]] | [[Category: Johnstone, S]] | ||
[[Category: Min, X]] | [[Category: Min, X]] | ||
| + | [[Category: Wang, Z]] | ||
| + | [[Category: Beta-klotho]] | ||
| + | [[Category: Fibroblast growth factor]] | ||
| + | [[Category: Scaffold protein]] | ||
| + | [[Category: Structural protein]] | ||
Revision as of 07:08, 25 July 2018
Crystal structure of KL with an agonist Fab
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