From Proteopedia
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Revision as of 07:20, 25 July 2018
proteopedia link proteopedia link Crystal structure of human indoleamime 2,3-dioxygenase (IDO1) in complex with L-Trp and cyanide, Northeast Structural Genomics Target HR6160
Structural highlights
6e35 is a 2 chain structure. Full crystallographic information is available from OCA . For a guided tour on the structure components use FirstGlance . Ligands: , , , Activity: Indoleamine 2,3-dioxygenase , with EC number 1.13.11.52 Resources: FirstGlance , OCA , PDBe , RCSB , PDBsum , ProSAT
Function
[I23O1_HUMAN ] Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.[1]
References
↑ Metz R, Duhadaway JB, Kamasani U, Laury-Kleintop L, Muller AJ, Prendergast GC. Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan. Cancer Res. 2007 Aug 1;67(15):7082-7. PMID:17671174 doi:http://dx.doi.org/10.1158/0008-5472.CAN-07-1872
Categories : Indoleamine 2,3-dioxygenase Forouhar, F Hussain, M Karkashon, S Lew, S Lewis-Ballester, A Lu, C Structural genomic Seetharaman, J Tong, L Yeh, S R 3-dioxygenate Nesg Oxidoreductase Psi-biology
