2l37

From Proteopedia

(Difference between revisions)

Revision as of 08:20, 25 July 2018

3D solution structure of arginine/glutamate-rich polypeptide Luffin P1 from the seeds of sponge gourd (Luffa cylindrical)

Structural highlights

2l37 is a 1 chain structure with sequence from Lufae. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Activity:	rRNA N-glycosylase, with EC number 3.2.2.22
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[RIP1_LUFAE] Inhibits protein synthesis in animal cells.^[1]

Publication Abstract from PubMed

Luffin P1, the smallest ribosome-inactivating peptide from the seeds of Luffa cylindrica was found to have anti-HIV-1 activity in HIV-1 infected C8166 T-cell lines and be able to bind with HIV Rev Response Element. Nuclear magnetic resonance spectroscopy revealed that the Luffin P1 comprises a helix-loop-helix motif, with the two alpha helices tightly associated by two disulfide bonds. Based on our findings, we conclude that unlike the well-studied ribosome-inactivating proteins, which exert their action through N-glycosidase activities, Luffin P1 demonstrates a novel inactivation mechanism probably through the charge complementation with viral or cellular proteins. Our work also provides a new scaffold for the design of novel inhibitors from a simple helical motif.

Structural characterization and anti-HIV-1 activities of arginine/glutamate-rich polypeptide Luffin P1 from the seeds of sponge gourd (Luffa cylindrica).,Ng YM, Yang Y, Sze KH, Zhang X, Zheng YT, Shaw PC J Struct Biol. 2010 Dec 31. PMID:21195767^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Li F, Yang XX, Xia HC, Zeng R, Hu WG, Li Z, Zhang ZC. Purification and characterization of Luffin P1, a ribosome-inactivating peptide from the seeds of Luffa cylindrica. Peptides. 2003 Jun;24(6):799-805. PMID:12948831
↑ Ng YM, Yang Y, Sze KH, Zhang X, Zheng YT, Shaw PC. Structural characterization and anti-HIV-1 activities of arginine/glutamate-rich polypeptide Luffin P1 from the seeds of sponge gourd (Luffa cylindrica). J Struct Biol. 2010 Dec 31. PMID:21195767 doi:10.1016/j.jsb.2010.12.007

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2l37"

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 ==3D solution structure of arginine/glutamate-rich polypeptide Luffin P1 from the seeds of sponge gourd (Luffa cylindrical)==
 <StructureSection load='2l37' size='340' side='right' caption='[[2l37]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
@@ Line 4: / Line 5: @@
 <table><tr><td colspan='2'>[[2l37]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lufae Lufae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L37 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L37 FirstGlance]. <br>
 </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l37 OCA], [http://pdbe.org/2l37 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l37 RCSB], [http://www.ebi.ac.uk/pdbsum/2l37 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l37 OCA], [http://pdbe.org/2l37 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l37 RCSB], [http://www.ebi.ac.uk/pdbsum/2l37 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2l37 ProSAT]</span></td></tr>
 </table>
 == Function ==

2l37

From Proteopedia

Revision as of 08:20, 25 July 2018

3D solution structure of arginine/glutamate-rich polypeptide Luffin P1 from the seeds of sponge gourd (Luffa cylindrical)

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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