Ion channels

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Line 50: Line 50:
**[[3bxl]] - rCav2.3 α 1E subunit+calmodulin<br />
**[[3bxl]] - rCav2.3 α 1E subunit+calmodulin<br />
**[[2f3y]], [[2f3z]], [[2be6]] – hCav1.2 α 1C subunit+calmodulin - human<br />
**[[2f3y]], [[2f3z]], [[2be6]] – hCav1.2 α 1C subunit+calmodulin - human<br />
 +
**[[5v2q]], [[5v2p]] - raCav1.2 1C + 2 - rat<br />
**[[1t0h]] – rVDCC β 2A subunit <br />
**[[1t0h]] – rVDCC β 2A subunit <br />
**[[1t0j]] – rVDCC β 2A+α 1C <br />
**[[1t0j]] – rVDCC β 2A+α 1C <br />
Line 58: Line 59:
**[[1t3s]] - rVDCC β 2<br />
**[[1t3s]] - rVDCC β 2<br />
**[[2d46]] – hVDCC β 4a – NMR<br />
**[[2d46]] – hVDCC β 4a – NMR<br />
 +
**[[5vov]], [[5vou]], [[5vot]], [[5kk2]] - raVDCC γ 2 + glutamate receptor – Cryo EM<br />
**[[3dve]], [[3dvj]], [[3dvk]], [[3dvm]], [[3g43]] - rCav2.2 α 1B subunit+hCalmodulin<br />
**[[3dve]], [[3dvj]], [[3dvk]], [[3dvm]], [[3g43]] - rCav2.2 α 1B subunit+hCalmodulin<br />
**[[4dex]] - rCav2.2 α 1B + β 2 subunits<br />
**[[4dex]] - rCav2.2 α 1B + β 2 subunits<br />
**[[4dey]] - rCav2.2 α 1C + β 2 subunits<br />
**[[4dey]] - rCav2.2 α 1C + β 2 subunits<br />
 +
**[[6byo]] – rCav1.1 α 1S <br />
 +
**[[5gjw]] – rCav1.1 α 2/δ 1 + α 1S + β 1 – Cryo EM<br />
 +
**[[5gjv]], [[3jbr]] – rCav1.1 α 2/δ 1 + α 1S + β 1 + γ 1 – Cryo EM<br />
**[[3oxq]] - hCav2.1 α 1C subunit IQ domain+hCalmodulin<br />
**[[3oxq]] - hCav2.1 α 1C subunit IQ domain+hCalmodulin<br />
**[[2vay]], [[3oxq]] - hCav1.1 α 1S subunit IQ domain+hCalmodulin<br />
**[[2vay]], [[3oxq]] - hCav1.1 α 1S subunit IQ domain+hCalmodulin<br />
**[[1hvd]], [[1hve]], [[1hvf]], [[1hvg]] – hAnnexin V (mutant)<br />
**[[1hvd]], [[1hve]], [[1hvf]], [[1hvg]] – hAnnexin V (mutant)<br />
 +
**[[6c9a]], [[6c96]] – mTpc1 - mouse <br />
 +
**[[4zw2]] – mVDCC α 1S peptide + β 1 <br />
 +
**[[5tua]], [[5e1j]], [[5dqq]] – Tpc1 – ''Arabidopsis thaliana'' <br />
*See also [[Ryanodine receptor]]
*See also [[Ryanodine receptor]]
Line 79: Line 87:
**[[4dck]], [[4jq0]] – hNaV 1.5 α C terminal + calmodulin + fibroblast growth factor <br />
**[[4dck]], [[4jq0]] – hNaV 1.5 α C terminal + calmodulin + fibroblast growth factor <br />
**[[4jpz]] – hNaV 1.2 α C terminal + calmodulin + fibroblast growth factor 13<br />
**[[4jpz]] – hNaV 1.2 α C terminal + calmodulin + fibroblast growth factor 13<br />
-
**[[1qg9]] – NaCh IIA second repeat – rat – NMR<br />
+
**[[1qg9]] – raNaCh IIA second repeat – NMR<br />
**[[4bgn]] – NaCh – ''Caldalkalibacillus thermarum'' – Cryo EM<br />
**[[4bgn]] – NaCh – ''Caldalkalibacillus thermarum'' – Cryo EM<br />
-
**[[4lto]], [[4ltp]], [[4ltq]] – AeNaCh pore + cytoplasmic domains – ''Alkalilimnicola ehrlichii'' <br />
+
**[[4lto]], [[4ltp]], [[4ltq]], [[5hk7]] – AeNaCh pore + cytoplasmic domains – ''Alkalilimnicola ehrlichii'' <br />
-
**[[4ltr]] – AeNaCh pore + cytoplasmic domains (mutant) <br />
+
**[[4ltr]], [[5hkd]], [[5hk6]], [[5kj8]] – AeNaCh pore + cytoplasmic domains (mutant) <br />
**[[5x0m]] – NaCh - cockroach <br />
**[[5x0m]] – NaCh - cockroach <br />
-
**[[5ayq]] - mNaV 4 residues 30-160 - mouse<br />
+
**[[5ayq]], [[5xax]], [[5xaw]] - mNaV 4 residues 30-160<br />
 +
**[[5yua]] - AbNaVab – ''Arcobacter butzleri''<br />
 +
**[[5yuc]], [[5yub]] - AbNaVab (mutant) <br />
 +
**[[5xsy]] – NaV 1.4 b1 – electric eel <br />
 +
**[[5x0m]] – NaV – cockroach <br />
* NH4+ channel
* NH4+ channel
Line 100: Line 112:
**[[2oar]] – MscL – ''Mycobacterium tuberculosis''<br />
**[[2oar]] – MscL – ''Mycobacterium tuberculosis''<br />
**[[4lku]] – EcMscL C terminal<br />
**[[4lku]] – EcMscL C terminal<br />
 +
**[[4y7k]], [[4y7j]] – MscL – Methanosarcina acetivorans<br />
**[[2oau]], [[2vv5]], [[4hwa]] - EcMscS<br />
**[[2oau]], [[2vv5]], [[4hwa]] - EcMscS<br />
**[[4age]], [[4agf]], [[5aji]] – EcMscS (mutant)<br />
**[[4age]], [[4agf]], [[5aji]] – EcMscS (mutant)<br />
Line 109: Line 122:
**[[1rk4]], [[3swl]] - hClCh protein 1<br />
**[[1rk4]], [[3swl]] - hClCh protein 1<br />
**[[3o3t]], [[3p8w]], [[3p90]], [[1k0o]], [[3qr6]], [[3tgz]], [[1k0m]], [[3uvh]], [[4iqa]], [[4jzq]], [[4k0g]], [[4k0n]] - hClCh protein 1 (mutant)<br />
**[[3o3t]], [[3p8w]], [[3p90]], [[1k0o]], [[3qr6]], [[3tgz]], [[1k0m]], [[3uvh]], [[4iqa]], [[4jzq]], [[4k0g]], [[4k0n]] - hClCh protein 1 (mutant)<br />
 +
**[[6coz]] - hClCh protein 1 C terminal<br />
 +
**[[6coy]] - hClCh protein 1 transmembrane domain<br />
**[[1k0n]] - hClCh protein 1 (mutant) + glutathione<br />
**[[1k0n]] - hClCh protein 1 (mutant) + glutathione<br />
**[[2per]], [[2r4v]], [[2r5g]] - hClCh protein 2<br />
**[[2per]], [[2r4v]], [[2r5g]] - hClCh protein 2<br />
Line 117: Line 132:
**[[1ots]] - EcERIC + antibody<br />
**[[1ots]] - EcERIC + antibody<br />
**[[1ott]], [[1otu]] - EcERIC (mutant) + antibody<br />
**[[1ott]], [[1otu]] - EcERIC (mutant) + antibody<br />
 +
**[[5tr1]], [[5tqq]] - bERIC (mutant) + antibody – Cryo EM<br />
**[[2d4z]] - TmClCh - ''Torpedo marmorata''<br />
**[[2d4z]] - TmClCh - ''Torpedo marmorata''<br />
**[[2yv9]] - CeClCh EXC-4 – ''Caenorhabditis elegans''<br />
**[[2yv9]] - CeClCh EXC-4 – ''Caenorhabditis elegans''<br />
**[[3rif]] - CeClCh + antibody + Glu + Ivermectin<br />
**[[3rif]] - CeClCh + antibody + Glu + Ivermectin<br />
**[[5tr1]], [[5tqq]] - bClCh + antibody - bovine<br />
**[[5tr1]], [[5tqq]] - bClCh + antibody - bovine<br />
 +
**[[6erz]], [[6ery]] - mClCh protein 6<br />
 +
**[[5y7i]] - ClCh – ''Oreochromis mossabicus''<br />
 +
 +
*CAMP-dependent chloride channel or cystic fibrosis transmembrane conductance regulator
 +
 +
**[[5uak]] - hClCh domains 1,R <br />
 +
**[[4wz6]], [[2pzg]] - hClCh domain 1 + ATP<br />
 +
**[[5tf7]], [[5tf8]], [[5tfa]], [[5tfb]], [[5tfc]], [[5tfd]], [[5tff]], [[5tfg]], [[5tfi]], [[5tfj]], [[5tgk]], [[4wz6]], [[2pzf]], [[2pze]], [[2bbt]], [[2bbs]], [[2bbo]], [[1xmj]], [[1xmi]], [[1xfa]], [[1xf9]], [[1r10]], [[1r0z]], [[1r0y]], [[1r0x]], [[1r0w]] - hClCh domain 1 (mutant) + nucleotide<br />
 +
**[[1q3h]] - mClCh domain 1<br />
 +
**[[3si7]] - mClCh domain 1 (mutant) + nucleotide<br />
 +
**[[5uar]], [[5w81]] - zeClCh - zebrafish <br />
 +
* Anion Channel (Outer mitochondrial membrane protein porin 1)
* Anion Channel (Outer mitochondrial membrane protein porin 1)
-
**[[2jk4]], [[2k4t]] – hVDAC1<br />
+
**[[2jk4]], [[2k4t]], [[5jdp]], [[5xdo]], [[5xdn]] – hVDAC1<br />
**[[3emn]], [[4c69]] – mVDAC1 <br />
**[[3emn]], [[4c69]] – mVDAC1 <br />
 +
**[[6g9o]], [[6g9l]], [[6g8z]] – mVDAC1 – Cryo EM<br />
 +
**[[6fnw]] – mVDAC1 C terminal<br />
**[[4bum]] – zeVDAC2 – zebra fish<br />
**[[4bum]] – zeVDAC2 – zebra fish<br />
Line 133: Line 163:
**[[2yks]], [[4twh]] - EchLGIC (mutant)<br />
**[[2yks]], [[4twh]] - EchLGIC (mutant)<br />
**[[2xq3]], [[2xq4]], [[2xq5]], [[2xq6]], [[2xq7]], [[2xqa]], [[2xq8]] – GvLGIC+inhibitor – ''Gloeobacter violaceus''<br />
**[[2xq3]], [[2xq4]], [[2xq5]], [[2xq6]], [[2xq7]], [[2xqa]], [[2xq8]] – GvLGIC+inhibitor – ''Gloeobacter violaceus''<br />
-
**[[3eam]], [[3ehz]], [[4hfi]], [[4il4]], [[4ilc]], [[4npp]], [[4npq]], [[4qh1]], [[4qh5]], [[4qh4]] – GvLGIC<br />
+
**[[3eam]], [[3ehz]], [[4hfi]], [[4il4]], [[4ilc]], [[4npp]], [[4npq]], [[4qh1]], [[4qh5]], [[4qh4]], [[6f7a]], [[6f16]], [[4zzc]] – GvLGIC<br />
**[[3igq]] – GvLGIC N-terminal<br />
**[[3igq]] – GvLGIC N-terminal<br />
**[[2xq9]] – GvLGIC (mutant)+inhibitor<br />
**[[2xq9]] – GvLGIC (mutant)+inhibitor<br />
**[[3p4w]], [[3p50]], [[4f8h]], [[4hfh]] – GvLGIC + general anaesthetic<br />
**[[3p4w]], [[3p50]], [[4f8h]], [[4hfh]] – GvLGIC + general anaesthetic<br />
-
**[[4hfd]] – GvLGIC (mutant) + general anaesthetic<br />
+
**[[4hfd]], [[5mvn]], [[5mvm]], [[5mur]], [[5muo]] – GvLGIC (mutant) + general anaesthetic<br />
**[[4hfc]], [[4hfe]] - GvLGIC (mutant) + alcohol<br />
**[[4hfc]], [[4hfe]] - GvLGIC (mutant) + alcohol<br />
-
**[[3lsv]], [[3tls]], [[3tlt]], [[3tlu]], [[3tlv]], [[3tlw]], [[3uu3]], [[3uu4]], [[3uu5]], [[3uu6]], [[3uu8]], [[3uub]], [[3ei0]], [[4hfb]], [[4il9]], [[4ila]], [[4ilb]], [[4ire]], [[4lmj]], [[4lmk]], [[4lml]], [[4zzb]], [[4zzc]], [[5hcj]], [[5hcm]], [[5heg]], [[5heh]], [[5iux]] – GvLGIC (mutant)<br />
+
**[[3lsv]], [[3tls]], [[3tlt]], [[3tlu]], [[3tlv]], [[3tlw]], [[3uu3]], [[3uu4]], [[3uu5]], [[3uu6]], [[3uu8]], [[3uub]], [[3ei0]], [[4hfb]], [[4il9]], [[4ila]], [[4ilb]], [[4ire]], [[4lmj]], [[4lmk]], [[4lml]], [[4zzb]], [[4zzc]], [[5hcj]], [[5hcm]], [[5heg]], [[5heh]], [[5iux]], [[6f15]], [[6f13]], [[6f12]], [[6f11]], [[6f10]], [[6f0z]], [[6f0v]], [[6f0u]], [[6f0r]], [[6f0n]], [[6f0m]], [[6f0j]], [[6f0i]], [[6emx]], [[5v6o]], [[5v6n]], [[5nkj]], [[5njy]], [[5mzt]], [[5mzr]], [[5mzq]], [[4zzb]] – GvLGIC (mutant)<br />
**[[5j0z]] - GvLGIC + choline derivative<br />
**[[5j0z]] - GvLGIC + choline derivative<br />
**[[5l47]], [[5l4e]], [[5l4h]] - GvLGIC + barbiturate<br />
**[[5l47]], [[5l4e]], [[5l4h]] - GvLGIC + barbiturate<br />
Line 152: Line 182:
* Cyclic Nucleotide-Gated channel
* Cyclic Nucleotide-Gated channel
-
**[[3etq]], [[3ffq]], [[3u0z]], [[3u10]], [[3u11]] - mCNGC C-terminal<br />
 
-
**[[1q3e]], [[1q43]], [[1q5o]] - mCNGC 2 fragment + nucleotide<br />
 
-
**[[2q0a]] - mCNGC 2 C-terminal (mutant)<br />
 
-
**[[3bpz]] - mCNGC 2 ligand-binding domain <br />
 
**[[2zd9]], [[3beh]] - MlCNGC - ''Mesorhizobium loti''<br />
**[[2zd9]], [[3beh]] - MlCNGC - ''Mesorhizobium loti''<br />
**[[4chv]], [[4chw]] – MlCNGC – Cryo EM<br />
**[[4chv]], [[4chw]] – MlCNGC – Cryo EM<br />
**[[2ptm]] - CNGC C-terminal - ''Strongylocentratus purpuratus''<br />
**[[2ptm]] - CNGC C-terminal - ''Strongylocentratus purpuratus''<br />
-
**[[3co2]] - MlCNGC ligand-binding domain (mutant) <br />
+
**[[2kxl]], [[1vp6]] - MlCNGC ligand-binding domain <br />
 +
**[[3co2]], [[4muv]], [[3clp]], [[1u12]] - MlCNGC ligand-binding domain (mutant) <br />
 +
**[[3cl1]], [[2k0g]] - MlCNGC ligand-binding domain + cyclic nucleotide<br />
**[[3swf]] - CNGC CLZ domain - bovine<br />
**[[3swf]] - CNGC CLZ domain - bovine<br />
 +
**[[5h3o]] – CeCNGC – Cryo EM<br />
 +
 +
*Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel
 +
 +
**[[3etq]], [[3ffq]], [[3u0z]], [[3u10]], [[3u11]] - mCNGC C-terminal<br />
 +
**[[1q3e]], [[1q43]], [[1q5o]] - mCNGC 2 fragment + nucleotide<br />
 +
**[[2q0a]] - mCNGC 2 C-terminal (mutant)<br />
 +
**[[3bpz]] - mCNGC 2 ligand-binding domain <br />
 +
**[[5u6o]], [[5u6p]] – hCNGC 1 – Cryo EM<br />
**[[2mpf]] – hCNGC 2 ligand-binding domain - NMR<br />
**[[2mpf]] – hCNGC 2 ligand-binding domain - NMR<br />
 +
**[[5khg]], [[5khh]], [[5khi]], [[5khj]], [[5khk]] – mCNGC 2 ligand-binding domain + nucleotide<br />
**[[3swy]] – hCNGC 3 CLZ domain<br />
**[[3swy]] – hCNGC 3 CLZ domain<br />
-
**[[2kxl]] - ligand-binding domain – NMR<br />
 
-
**[[3beh]] - MlCNGC<br />
 
**[[3otf]] – hCNGC 4 ligand-binding domain<br />
**[[3otf]] – hCNGC 4 ligand-binding domain<br />
**[[2mng]] – hCNGC 4 ligand-binding domain - NMR<br />
**[[2mng]] – hCNGC 4 ligand-binding domain - NMR<br />
Line 173: Line 209:
* Acid sensitive ion channel
* Acid sensitive ion channel
-
**[[3ij4]], [[2qts]], [[3s3w]], [[4nyk]], [[3ij4]] – cASC – chicken<br />
+
**[[3ij4]], [[2qts]], [[3s3w]], [[4nyk]], [[3ij4]], [[6ave]], [[5wku]], [[5wkv]] – cASC – chicken<br />
**[[3s3x]], [[4fz0]], [[4fz1]] – cASC + psalmotoxin<br />
**[[3s3x]], [[4fz0]], [[4fz1]] – cASC + psalmotoxin<br />
**[[4ntw]], [[4ntx]], [[4nty]] - cASC + neurotoxin + basic phospholipase A2<br />
**[[4ntw]], [[4ntx]], [[4nty]] - cASC + neurotoxin + basic phospholipase A2<br />
Line 183: Line 219:
**[[4dw1]] – zeAGC + ATP<br />
**[[4dw1]] – zeAGC + ATP<br />
-
* Proton channel
+
* Proton channel or matrix protein 2
**[[2kih]], [[2kwx]] – IVproton channel – Influenza virus<br />
**[[2kih]], [[2kwx]] – IVproton channel – Influenza virus<br />
**[[2rtf]] - IVproton channel + inhibitor - NMR<br />
**[[2rtf]] - IVproton channel + inhibitor - NMR<br />
**[[3c9j]] - IVproton channel transmembrane domain + inhibitor<br />
**[[3c9j]] - IVproton channel transmembrane domain + inhibitor<br />
-
**[[3bkd]] - IVproton channel transmembrane domain<br />
+
**[[3bkd]], [[4qkm]], [[4qkl]], [[4qkc]], [[4qk7]], [[3lbw]] - IVproton channel transmembrane domain<br />
-
**[[1nyj]], [[1mp6]] - IVproton channel transmembrane domain - NMR<br />
+
**[[1nyj]], [[1mp6]], [[2kad]] - IVproton channel transmembrane domain - NMR<br />
-
**[[2kj1]], [[2l0j]] - IVproton channel – NMR
+
**[[2kj1]], [[2l0j]] - IVproton channel – NMR<br />
 +
**[[5c02]], [[4rwc]], [[4rwb]], [[2kih]] - IVproton channel transmembrane domain (mutant)<br />
 +
**[[2n70]] - IVproton channel transmembrane domain (mutant) - NMR<br />
 +
**[[2kqt]] - IVproton channel transmembrane domain + drug - NMR<br />
 +
**[[2ly0]] - IVproton channel transmembrane domain (mutant) + drug - NMR<br />
 +
 
* Voltage-gated hydrogen channel (VGHC)
* Voltage-gated hydrogen channel (VGHC)

Revision as of 09:30, 29 July 2018

Voltage-dependent potassium channel β subunit core complex with NADPH, 1qrq

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3D structures of ion channels

Updated on 29-July-2018



Weblinks

References

  1. ↑ Szewczyk A, Jarmuszkiewicz W, Kunz WS. Mitochondrial potassium channels. IUBMB Life. 2009 Feb;61(2):134-43. doi: 10.1002/iub.155. PMID:19165895 doi:http://dx.doi.org/10.1002/iub.155
  2. ↑ Venkatachalam K, Montell C. TRP channels. Annu Rev Biochem. 2007;76:387-417. PMID:17579562 doi:http://dx.doi.org/10.1146/annurev.biochem.75.103004.142819
  3. ↑ Zadek B, Nimigean CM. Calcium-dependent gating of MthK, a prokaryotic potassium channel. J Gen Physiol. 2006 Jun;127(6):673-85. PMID:16735753 doi:http://dx.doi.org/10.1085/jgp.200609534
  4. ↑ Kloda A, Martinac B. Mechanosensitive channels of bacteria and archaea share a common ancestral origin. Eur Biophys J. 2002 Mar;31(1):14-25. PMID:12046893
  5. ↑ Lacinova L. Voltage-dependent calcium channels. Gen Physiol Biophys. 2005 Jun;24 Suppl 1:1-78. PMID:16096350
  6. ↑ Shoshan-Barmatz V, Israelson A, Brdiczka D, Sheu SS. The voltage-dependent anion channel (VDAC): function in intracellular signalling, cell life and cell death. Curr Pharm Des. 2006;12(18):2249-70. PMID:16787253
  7. ↑ Keramidas A, Moorhouse AJ, Schofield PR, Barry PH. Ligand-gated ion channels: mechanisms underlying ion selectivity. Prog Biophys Mol Biol. 2004 Oct;86(2):161-204. PMID:15288758 doi:http://dx.doi.org/10.1016/j.pbiomolbio.2003.09.002
  8. ↑ Kaupp UB, Seifert R. Cyclic nucleotide-gated ion channels. Physiol Rev. 2002 Jul;82(3):769-824. PMID:12087135 doi:http://dx.doi.org/10.1152/physrev.00008.2002
  9. ↑ Holzer P. Acid-sensitive ion channels and receptors. Handb Exp Pharmacol. 2009;(194):283-332. doi: 10.1007/978-3-540-79090-7_9. PMID:19655111 doi:http://dx.doi.org/10.1007/978-3-540-79090-7_9
  10. ↑ Stroud RM, Miercke LJ, O'Connell J, Khademi S, Lee JK, Remis J, Harries W, Robles Y, Akhavan D. Glycerol facilitator GlpF and the associated aquaporin family of channels. Curr Opin Struct Biol. 2003 Aug;13(4):424-31. PMID:12948772
  11. ↑ Ruan Y, Liu N, Priori SG. Sodium channel mutations and arrhythmias. Nat Rev Cardiol. 2009 May;6(5):337-48. doi: 10.1038/nrcardio.2009.44. PMID:19377496 doi:http://dx.doi.org/10.1038/nrcardio.2009.44
  12. ↑ Meisler MH, Kearney JA. Sodium channel mutations in epilepsy and other neurological disorders. J Clin Invest. 2005 Aug;115(8):2010-7. PMID:16075041 doi:http://dx.doi.org/10.1172/JCI25466
  13. ↑ Watanabe H, Koopmann TT, Le Scouarnec S, Yang T, Ingram CR, Schott JJ, Demolombe S, Probst V, Anselme F, Escande D, Wiesfeld AC, Pfeufer A, Kaab S, Wichmann HE, Hasdemir C, Aizawa Y, Wilde AA, Roden DM, Bezzina CR. Sodium channel beta1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans. J Clin Invest. 2008 Jun;118(6):2260-8. doi: 10.1172/JCI33891. PMID:18464934 doi:http://dx.doi.org/10.1172/JCI33891
  14. ↑ Dworakowska B, Dolowy K. Ion channels-related diseases. Acta Biochim Pol. 2000;47(3):685-703. PMID:11310970
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