Kinesin

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Line 90: Line 90:
**[[4hna]], [[4lnu]] – hKIF1 + Tubulin + designed ankyrin repeat protein + Mg-ADP + GDP + GTP + AlF4<br />
**[[4hna]], [[4lnu]] – hKIF1 + Tubulin + designed ankyrin repeat protein + Mg-ADP + GDP + GTP + AlF4<br />
**[[4uxy]] – hKIF1 MD + Tubulin + GDP + GTP – Cryo EM<br />
**[[4uxy]] – hKIF1 MD + Tubulin + GDP + GTP – Cryo EM<br />
 +
**[[4uy0]] – hKIF1 MD + Tubulin + GDP + GTP + ADP – Cryo EM<br />
**[[2p4n]] – hKIF+ Tubulin – EM docking<br />
**[[2p4n]] – hKIF+ Tubulin – EM docking<br />
**[[5mio]] – hKIF2C MD + Tubulin <br />
**[[5mio]] – hKIF2C MD + Tubulin <br />
Line 107: Line 108:
*Kinesin light chain (KLC)
*Kinesin light chain (KLC)
 +
**[[5oj8]] – hKLC1 TPR domain <br />
**[[3edt]] – hKLC2<br />
**[[3edt]] – hKLC2<br />
**[[3ceq]], [[3nf1]] – hKLC2 TPR domain<br />
**[[3ceq]], [[3nf1]] – hKLC2 TPR domain<br />
 +
**[[5ojf]] – mKLC2 TPR domain <br />
**[[3zfw]], [[5fjy]] - mKLC2 TPR domain + peptide<br />
**[[3zfw]], [[5fjy]] - mKLC2 TPR domain + peptide<br />
 +
**[[6fv0]] – mKLC1 TPR domain + nanobody<br />
*Kinesin-3 motor domain
*Kinesin-3 motor domain
**[[4uxo]], [[4uxp]], [[4uxr]], [[4uxs]], [[4uxt]] - KIF + tubulin 1B, 2B chains + GDP + GTP – bovine – Cryo EM <br />
**[[4uxo]], [[4uxp]], [[4uxr]], [[4uxs]], [[4uxt]] - KIF + tubulin 1B, 2B chains + GDP + GTP – bovine – Cryo EM <br />
 +
**[[5zbs]] – rKIF13B (mutant)<br />
 +
**[[5zbr]] – rKIF13B + AMPPNP<br />
 +
**[[5b64]] – mKIF13B + MAGUK<br />
*Kinesin-5 motor domain
*Kinesin-5 motor domain
Line 133: Line 140:
**[[4ck5]], [[4ck6]], [[4ck7]] – hKIF11 (mutant) + tubulin + ADP + GDP + GTP + Mg – Cryo EM<br />
**[[4ck5]], [[4ck6]], [[4ck7]] – hKIF11 (mutant) + tubulin + ADP + GDP + GTP + Mg – Cryo EM<br />
**[[4pxt]], [[4pxu]] – DmKIF (mutant)<br />
**[[4pxt]], [[4pxu]] – DmKIF (mutant)<br />
-
**[[5m5i]], [[5m5l]], [[5m5m]], [[5m5n]], [[5m5o]] – KIF + tubulin + GDP + GTP + ANP + axol – fission yeast – Cryo EM<br />
+
**[[5m5i]], [[5m5l]], [[5m5m]], [[5m5n]], [[5m5o]] – KIF + tubulin + GDP + GTP + ANP + taxol – fission yeast – Cryo EM<br />
 +
**[[5mm4]] – KIF + tubulin + GDP + GTP + ANP + taxol – Ustilago maydis – Cryo EM<br />
*Kinesin-6
*Kinesin-6

Revision as of 08:28, 30 July 2018

KIF1A Motor Domain complex with ADP and Mg+2 ion (green), 2zfi

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3D Structures of Kinesin

Updated on 30-July-2018

References

  1. ↑ Hirokawa N, Noda Y, Tanaka Y, Niwa S. Kinesin superfamily motor proteins and intracellular transport. Nat Rev Mol Cell Biol. 2009 Oct;10(10):682-96. doi: 10.1038/nrm2774. PMID:19773780 doi:http://dx.doi.org/10.1038/nrm2774
  2. ↑ Ebbing B, Mann K, Starosta A, Jaud J, Schols L, Schule R, Woehlke G. Effect of spastic paraplegia mutations in KIF5A kinesin on transport activity. Hum Mol Genet. 2008 May 1;17(9):1245-52. doi: 10.1093/hmg/ddn014. Epub 2008 Jan, 18. PMID:18203753 doi:http://dx.doi.org/10.1093/hmg/ddn014
  3. ↑ Hirokawa N, Takemura R. Biochemical and molecular characterization of diseases linked to motor proteins. Trends Biochem Sci. 2003 Oct;28(10):558-65. PMID:14559185 doi:http://dx.doi.org/10.1016/j.tibs.2003.08.006
  4. ↑ Grosch M, Gruner B, Spranger S, Stutz AM, Rausch T, Korbel JO, Seelow D, Nurnberg P, Sticht H, Lausch E, Zabel B, Winterpacht A, Tagariello A. Identification of a Ninein (NIN) mutation in a family with spondyloepimetaphyseal dysplasia with joint laxity (leptodactylic type)-like phenotype. Matrix Biol. 2013 Oct-Nov;32(7-8):387-92. doi: 10.1016/j.matbio.2013.05.001. Epub, 2013 May 9. PMID:23665482 doi:http://dx.doi.org/10.1016/j.matbio.2013.05.001
  5. ↑ Nitta R, Okada Y, Hirokawa N. Structural model for strain-dependent microtubule activation of Mg-ADP release from kinesin. Nat Struct Mol Biol. 2008 Oct;15(10):1067-75. Epub 2008 Sep 21. PMID:18806800 doi:10.1038/nsmb.1487
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