Macrophage inhibitory factor

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<StructureSection load='2ooh' size='400' side='right' caption='Structure of human macrophage inhibitory factor trimer complex with inhibitor, glycerol and sulfate (PDB entry [[2ooh]])' scene='55/551208/Cv/1'>
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<StructureSection load='2ooh' size='350' side='right' caption='Structure of human macrophage inhibitory factor trimer complex with inhibitor, glycerol and sulfate (PDB entry [[2ooh]])' scene='55/551208/Cv/1'>
== Function ==
== Function ==
'''Macrophage inhibitory factor''' (MIF) is an inflammatory cytokine. MIF is released to the blood stream upon stimulation of white blood cells by bacterial antigens<ref>PMID:11032394</ref>.
'''Macrophage inhibitory factor''' (MIF) is an inflammatory cytokine. MIF is released to the blood stream upon stimulation of white blood cells by bacterial antigens<ref>PMID:11032394</ref>.
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**[[1mif]] – MIF (mutant) – rat<BR />
**[[1mif]] – MIF (mutant) – rat<BR />
**[[1fim]], [[1gif]], [[1gd0]], [[3djh]] – hMIF – human<BR />
**[[1fim]], [[1gif]], [[1gd0]], [[3djh]] – hMIF – human<BR />
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**[[1cgq]], [[1p1g]], [[4etg]], [[4eui]], [[4evg]], [[4grn]], [[4gro]], [[4grp]], [[4grq]], [[4grr]], [[4gru]] – hMIF (mutant) <BR />
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**[[1cgq]], [[1p1g]], [[4etg]], [[4eui]], [[4evg]], [[4grn]], [[4gro]], [[4grp]], [[4grq]], [[4grr]], [[4gru]], [[6bg6]], [[6bg7]], [[5v73]], [[5v70]], [[5uzy]], [[5umk]], [[5umj]], [[5hvv]], [[5hvt]], [[5hvs]], [[5eiz]], [[5bsj]], [[5bsi]], [[5bsc]], [[5bs9]], [[4xx8]], [[4xx7]], [[4tru]], [[4trf]], [[4pkz]], [[4pkk]] – hMIF (mutant) <BR />
**[[1mff]] – mMIF (mutant) – mouse<BR />
**[[1mff]] – mMIF (mutant) – mouse<BR />
**[[1hfo]] – MIF – ''Trichinella spiralis'' <BR />
**[[1hfo]] – MIF – ''Trichinella spiralis'' <BR />
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**[[1ca7]] – hMIF + hydroxyphenylpyruvate<BR />
**[[1ca7]] – hMIF + hydroxyphenylpyruvate<BR />
**[[3ijj]] – hMIF + hydroxyphenylpyruvate + inhibitor<BR />
**[[3ijj]] – hMIF + hydroxyphenylpyruvate + inhibitor<BR />
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**[[1gcz]], [[1ljt]], [[2ooh]], [[2oow]], [[2ooz]], [[3b9s]], [[3jsf]], [[3jsg]], [[3jtu]], [[3l5p]], [[3l5r]], [[3l5s]], [[3l5t]], [[3l5u]], [[3l5v]], [[3ijg]], [[4f2k]], [[3smb]], [[3smc]], [[3wnr]], [[3wns]], [[3wnt]], [[4osf]], [[4p01]], [[4k9g]], [[4oyq]], [[4p0h]], [[4wr8]], [[4wrb]] – hMIF + inhibitor <BR />
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**[[1gcz]], [[1ljt]], [[2ooh]], [[2oow]], [[2ooz]], [[3b9s]], [[3jsf]], [[3jsg]], [[3jtu]], [[3l5p]], [[3l5r]], [[3l5s]], [[3l5t]], [[3l5u]], [[3l5v]], [[3ijg]], [[4f2k]], [[3smb]], [[3smc]], [[3wnr]], [[3wns]], [[3wnt]], [[4osf]], [[4p01]], [[4k9g]], [[4oyq]], [[4p0h]], [[4wr8]], [[4wrb]], [[6b1c]], [[6b1k]], [[6b2c]], [[6cb5]], [[6bcf]], [[6cbg]], [[6cbh]], [[6fve]], [[6fvh]], [[5xej]], [[5j7q]], [[5j7p]], [[5b4o]], [[4z1u]], [[4z1t]], [[4z15]], [[4plu]] – hMIF + inhibitor <BR />
**[[3dji]] – hMIF + tylenol<BR />
**[[3dji]] – hMIF + tylenol<BR />
**[[3ce4]] – hMIF + PMSF<BR />
**[[3ce4]] – hMIF + PMSF<BR />

Revision as of 10:27, 1 August 2018

Structure of human macrophage inhibitory factor trimer complex with inhibitor, glycerol and sulfate (PDB entry 2ooh)

Drag the structure with the mouse to rotate

3D structures of macrophage inhibitory factor

Updated on 01-August-2018

References

  1. ↑ Nishihira J. Macrophage migration inhibitory factor (MIF): its essential role in the immune system and cell growth. J Interferon Cytokine Res. 2000 Sep;20(9):751-62. PMID:11032394 doi:http://dx.doi.org/10.1089/10799900050151012
  2. ↑ Bach JP, Deuster O, Balzer-Geldsetzer M, Meyer B, Dodel R, Bacher M. The role of macrophage inhibitory factor in tumorigenesis and central nervous system tumors. Cancer. 2009 May 15;115(10):2031-40. doi: 10.1002/cncr.24245. PMID:19326434 doi:http://dx.doi.org/10.1002/cncr.24245
  3. ↑ Shimizu T. Role of macrophage migration inhibitory factor (MIF) in the skin. J Dermatol Sci. 2005 Feb;37(2):65-73. PMID:15659324 doi:http://dx.doi.org/10.1016/j.jdermsci.2004.08.007
  4. ↑ Bacher M, Deuster O, Aljabari B, Egensperger R, Neff F, Jessen F, Popp J, Noelker C, Reese JP, Al-Abed Y, Dodel R. The role of macrophage migration inhibitory factor in Alzheimer's disease. Mol Med. 2010 Mar;16(3-4):116-21. doi: 10.2119/molmed.2009.00123. Epub 2010 Feb, 28. PMID:20200619 doi:http://dx.doi.org/10.2119/molmed.2009.00123
  5. ↑ Crichlow GV, Cheng KF, Dabideen D, Ochani M, Aljabari B, Pavlov VA, Miller EJ, Lolis E, Al-Abed Y. Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor. J Biol Chem. 2007 Aug 10;282(32):23089-95. Epub 2007 May 25. PMID:17526494 doi:http://dx.doi.org/10.1074/jbc.M701825200

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Michal Harel, Alexander Berchansky

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