5wkz

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m (Protected "5wkz" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5wkz is ON HOLD until Paper Publication
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==VH1-69 germline antibody predicted from CR6261==
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<StructureSection load='5wkz' size='340' side='right' caption='[[5wkz]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5wkz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WKZ FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wkz OCA], [http://pdbe.org/5wkz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wkz RCSB], [http://www.ebi.ac.uk/pdbsum/5wkz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wkz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/HV69D_HUMAN HV69D_HUMAN]] V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).<ref>PMID:17576170</ref> <ref>PMID:20176268</ref> <ref>PMID:22158414</ref> <ref>PMID:24600447</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Lang, S]]
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[[Category: Lee, P S]]
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[[Category: Cr6261]]
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[[Category: Immune system]]
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[[Category: Vh1-69 germline]]

Revision as of 18:36, 1 August 2018

VH1-69 germline antibody predicted from CR6261

5wkz, resolution 1.85Å

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