2oix
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= xopD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=456327 Xanthomonas euvesicatoria]) | |GENE= xopD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=456327 Xanthomonas euvesicatoria]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2oiv|2OIV]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oix OCA], [http://www.ebi.ac.uk/pdbsum/2oix PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2oix RCSB]</span> | ||
}} | }} | ||
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[[Category: type iii secreted effector]] | [[Category: type iii secreted effector]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:18:28 2008'' |
Revision as of 01:18, 31 March 2008
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| , resolution 1.80Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | xopD (Xanthomonas euvesicatoria) | ||||||
| Related: | 2OIV
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Xanthomonas XopD C470A Mutant
Overview
XopD (Xanthomonas outer protein D), a type III secreted effector from Xanthomonas campestris pv. vesicatoria, is a desumoylating enzyme with strict specificity for its plant small ubiquitin-like modifier (SUMO) substrates. Based on SUMO sequence alignments and peptidase assays with various plant, yeast, and mammalian SUMOs, we identified residues in SUMO that contribute to XopD/SUMO recognition. Further predictions regarding the enzyme/substrate specificity were made by solving the XopD crystal structure. By incorporating structural information with sequence alignments and enzyme assays, we were able to elucidate determinants of the rigid SUMO specificity exhibited by the Xanthomonas virulence factor XopD.
About this Structure
2OIX is a Single protein structure of sequence from Xanthomonas euvesicatoria. Full crystallographic information is available from OCA.
Reference
Structural analysis of Xanthomonas XopD provides insights into substrate specificity of ubiquitin-like protein proteases., Chosed R, Tomchick DR, Brautigam CA, Mukherjee S, Negi VS, Machius M, Orth K, J Biol Chem. 2007 Mar 2;282(9):6773-82. Epub 2007 Jan 3. PMID:17204475
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