Malate synthase
From Proteopedia
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| - | <StructureSection load='2gq3' size=' | + | <StructureSection load='2gq3' size='350' side='right' caption='Structure of malate synthase G complex with CoA, malate, Hepes and Mg+2 ion (green) (PDB entry [[2gq3]])' scene='57/573146/Cv/1'> |
== Function == | == Function == | ||
'''Malate synthase''' (MS) catalyzes the reversible conversion of acetyl-CoA, glyoxylate and water to (S)-malate and CoA. MS participates in pyruvate, glyoxylate and dicarboxylate metabolism. There are 2 isozymes of MS. '''MS G''' is formed during growth on glycolate<ref>PMID:12930982</ref> and '''MS A''' which metabolizes glyoxylate formed in the dissimilation of acetate. | '''Malate synthase''' (MS) catalyzes the reversible conversion of acetyl-CoA, glyoxylate and water to (S)-malate and CoA. MS participates in pyruvate, glyoxylate and dicarboxylate metabolism. There are 2 isozymes of MS. '''MS G''' is formed during growth on glycolate<ref>PMID:12930982</ref> and '''MS A''' which metabolizes glyoxylate formed in the dissimilation of acetate. | ||
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**[[3cuz]], [[3cv1]] – EcMS A<br /> | **[[3cuz]], [[3cv1]] – EcMS A<br /> | ||
**[[4ex4]] – MS G + Mg – ''Mycobacterium leprae''<br /> | **[[4ex4]] – MS G + Mg – ''Mycobacterium leprae''<br /> | ||
| + | **[[5h8p]] – MtMS G – ''Mycobacterium tuberculosis''<br /> | ||
| + | **[[5h8m]] – MtMS G (mutant) + Mg <br /> | ||
**[[3cux]] – MS + Mg – ''Bacillus anthracis''<br /> | **[[3cux]] – MS + Mg – ''Bacillus anthracis''<br /> | ||
| + | **[[5oas]] – PaMS G + Mg – ''Pseudomonas aeruginosa''<br /> | ||
*Malate synthase binary complex | *Malate synthase binary complex | ||
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**[[1d8c]] – EcMS G (mutant) + glyoxylate + Mg <br /> | **[[1d8c]] – EcMS G (mutant) + glyoxylate + Mg <br /> | ||
**[[3cv2]] – EcMS A + oxalate + Mg <br /> | **[[3cv2]] – EcMS A + oxalate + Mg <br /> | ||
| - | **[[1n8i]] – MtMS G + glyoxylate + Mg – | + | **[[1n8i]] – MtMS G + glyoxylate + Mg <br /> |
| - | **[[ | + | **[[5h8u]] – MtMS G + malate + Mg <br /> |
| + | **[[56axe]] – MtMS G + acetyl CoA + Mg <br /> | ||
| + | **[[5c7v]], [[5cah]], [[5cjm]], [[5e9x]] – MtMS G (mutant) + pyrrole derivative + Mg <br /> | ||
| + | **[[5cew]] – MtMS G (mutant) + pyridine derivative + Mg <br /> | ||
| + | **[[5cjn]] – MtMS G (mutant) + quinoxaline derivative + Mg <br /> | ||
| + | **[[5dx7]] – MtMS G (mutant) + isoxazole derivative + Mg <br /> | ||
| + | **[[5c9r]], [[5c9u]], [[5c9w]], [[5cbj]], [[5ccz]] – MtMS G (mutant) + phenyl derivative + Mg <br /> | ||
| + | **[[5c9x]], [[5cbi]] – MtMS G (mutant) + benzoate derivative + Mg <br /> | ||
| + | **[[5cak]], [[5cbb]], [[5cc3]], [[5cc5]], [[5cc6]], [[5cc7]], [[5drc]], [[5dri]], [[5ecv]] – MtMS G (mutant) + indole derivative + Mg <br /> | ||
| + | **[[5t8g]] – MtMS G (mutant) + thiophene derivative + Mg <br /> | ||
**[[3s9i]], [[3s9z]], [[3sad]], [[3saz]], [[3sb0]] – MtMS G (mutant) + inhibitor + Mg <br /> | **[[3s9i]], [[3s9z]], [[3sad]], [[3saz]], [[3sb0]] – MtMS G (mutant) + inhibitor + Mg <br /> | ||
| + | **[[3oyx]], [[3pug]] – HvMS G + glyoxylate + Mg – ''Haloferax volcanii''<br /> | ||
| + | **[[5tao]] – HvMS G + glyoxylate + Pb<br /> | ||
| + | **[[5vfb]] – PaMS + glycolate + Ni<br /> | ||
*Malate synthase ternary complex | *Malate synthase ternary complex | ||
Revision as of 09:56, 2 August 2018
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3d structures of malate synthase
Updated on 02-August-2018
References
- ↑ Anstrom DM, Kallio K, Remington SJ. Structure of the Escherichia coli malate synthase G:pyruvate:acetyl-coenzyme A abortive ternary complex at 1.95 A resolution. Protein Sci. 2003 Sep;12(9):1822-32. PMID:12930982
- ↑ Anstrom DM, Remington SJ. The product complex of M. tuberculosis malate synthase revisited. Protein Sci. 2006 Aug;15(8):2002-7. PMID:16877713 doi:15/8/2002
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