This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Mitogen-activated protein kinase
From Proteopedia
(Difference between revisions)
| Line 25: | Line 25: | ||
*MAPK1 | *MAPK1 | ||
**[[4g6n]], [[4g6o]], [[4gsb]] – hMAPK1 - human<br /> | **[[4g6n]], [[4g6o]], [[4gsb]] – hMAPK1 - human<br /> | ||
| - | **[[3i5z]], [[3i60]], [[3w55]], [[2ojg]], [[2oji]], [[2ojj]], [[1wzy]], [[1tvo]], [[3sa0]], [[4fux]], [[4fuy]], [[4fv0]], [[4fv1]], [[4fv2]], [[4fv3]], [[4fv4]], [[4fv5]], [[4fv6]], [[4fv7]], [[4fv8]], [[4fv9]], [[4n4s]], [[4o6e]], [[4qp1]], [[4qp2]], [[4qp3]], [[4qp4]], [[4qp6]], [[4qp7]], [[4qp8]], [[4qp9]] [[4qpa]], [[4qta]], [[4qte]], [[4xj0]], [[4xne]], [[4xoy]], [[4xoz]], [[4xp0]], [[4xp2]], [[4xp3]], [[4xrj]], [[4xrl]], [[4zzm]], [[4zzn]], [[4zzo]], [[5bue]], [[5bui]], [[5buj]], [[5bvd]], [[5bve]], [[5bvf]], [[5hd4]], [[5hd7]], [[5k4i]], [[5ke0]], [[5lcj]], [[5lck]], [[5ngu]], [[5nhf]], [[5nhh]], [[5nhj]], [[5nhl]], [[5nho]], [[5nhp]], [[5nhv]], [[5u6i]] – hMAPK1+inhibitor - human<br /> | + | **[[3i5z]], [[3i60]], [[3w55]], [[2ojg]], [[2oji]], [[2ojj]], [[1wzy]], [[1tvo]], [[3sa0]], [[4fux]], [[4fuy]], [[4fv0]], [[4fv1]], [[4fv2]], [[4fv3]], [[4fv4]], [[4fv5]], [[4fv6]], [[4fv7]], [[4fv8]], [[4fv9]], [[4n4s]], [[4o6e]], [[4qp1]], [[4qp2]], [[4qp3]], [[4qp4]], [[4qp6]], [[4qp7]], [[4qp8]], [[4qp9]] [[4qpa]], [[4qta]], [[4qte]], [[4xj0]], [[4xne]], [[4xoy]], [[4xoz]], [[4xp0]], [[4xp2]], [[4xp3]], [[4xrj]], [[4xrl]], [[4zzm]], [[4zzn]], [[4zzo]], [[5bue]], [[5bui]], [[5buj]], [[5bvd]], [[5bve]], [[5bvf]], [[5hd4]], [[5hd7]], [[5k4i]], [[5ke0]], [[5lcj]], [[5lck]], [[5ngu]], [[5nhf]], [[5nhh]], [[5nhj]], [[5nhl]], [[5nho]], [[5nhp]], [[5nhv]], [[5u6i]], [[6g8x]], [[6g91]], [[6g92]], [[6g93]], [[6g97]], [[6g9a]], [[6g9d]], [[6g9h]], [[6g9j]], [[6g9k]], [[6g9m]], [[6g9n]], [[6gdm]], [[6gdq]], [[6ge0]], [[6dcg]], [[5wp1]] – hMAPK1+inhibitor - human<br /> |
**[[2y9q]] – hMAPK1 + MAP kinase-interacting Ser/Thr protein kinase peptide<br /> | **[[2y9q]] – hMAPK1 + MAP kinase-interacting Ser/Thr protein kinase peptide<br /> | ||
**[[3tei]], [[4h3p]], [[4nif]] – hMAPK1 (mutant) + ribosomal protein S6 kinase α-1<br /> | **[[3tei]], [[4h3p]], [[4nif]] – hMAPK1 (mutant) + ribosomal protein S6 kinase α-1<br /> | ||
**[[4iz5]], [[4iz7]], [[4iza]] – hMAPK1 (mutant) + astrocytic phosphoprotein <br /> | **[[4iz5]], [[4iz7]], [[4iza]] – hMAPK1 (mutant) + astrocytic phosphoprotein <br /> | ||
**[[4fmq]] – hMAPK1 + MAPK docking peptide<br /> | **[[4fmq]] – hMAPK1 + MAPK docking peptide<br /> | ||
| + | **[[5v62]], [[5v61]] – hMAPK1 + ERK2 peptide + inhibitor<br /> | ||
**[[4h3q]] – hMAPK1 + MAP2K 2 peptide<br /> | **[[4h3q]] – hMAPK1 + MAP2K 2 peptide<br /> | ||
**[[5ax3]] – hMAPK1 + allosteric inhibitor peptide<br /> | **[[5ax3]] – hMAPK1 + allosteric inhibitor peptide<br /> | ||
**[[4n0s]] – hMAPK1 + cafeic acid<br /> | **[[4n0s]] – hMAPK1 + cafeic acid<br /> | ||
**[[4zxt]] – hMAPK1 + catechol<br /> | **[[4zxt]] – hMAPK1 + catechol<br /> | ||
| - | **[[2z7l]], [[3c9w]], [[3qyw]], [[3qyz]], [[4qyy]] - rMAPK1+inhibitor – rat<br /> | + | **[[5v60]] – hMAPK1 + ACP<br /> |
| + | **[[2z7l]], [[3c9w]], [[3qyw]], [[3qyz]], [[4qyy]], [[6cpw]] - rMAPK1+inhibitor – rat<br /> | ||
**[[1erk]], [[4s31]], [[5umo]] - rMAPK1<br /> | **[[1erk]], [[4s31]], [[5umo]] - rMAPK1<br /> | ||
**[[1gol]], [[3r63]], [[4s2z]], [[4s30]] - rMAPK1 (mutant)<br /> | **[[1gol]], [[3r63]], [[4s2z]], [[4s30]] - rMAPK1 (mutant)<br /> | ||
| Line 77: | Line 79: | ||
**[[4ic8]] – hMAPK7<br /> | **[[4ic8]] – hMAPK7<br /> | ||
| - | **[[4b99]], [[4zsg]], [[4zsj]], [[4zsl]], [[5byy]], [[5byz]] – hMAPK7+inhibitor<br /> | + | **[[4b99]], [[4zsg]], [[4zsj]], [[4zsl]], [[5byy]], [[5byz]], [[5o7i]] – hMAPK7+inhibitor<br /> |
**[[4ic7]] – hMAPK7+ MAP2K 5<br /> | **[[4ic7]] – hMAPK7+ MAP2K 5<br /> | ||
| Line 84: | Line 86: | ||
**[[3o17]], [[2gmx]], [[2g01]], [[3vud]], [[3vug]], [[3vuh]], [[3vui]], [[3vuk]], [[3vul]], [[3vum]] – hMAPK8 (mutant)+JIP1 peptide<br /> | **[[3o17]], [[2gmx]], [[2g01]], [[3vud]], [[3vug]], [[3vuh]], [[3vui]], [[3vuk]], [[3vul]], [[3vum]] – hMAPK8 (mutant)+JIP1 peptide<br /> | ||
**[[1ukh]], [[1uki]] - jMAPK8 JNK1+JIP1 peptide<br /> | **[[1ukh]], [[1uki]] - jMAPK8 JNK1+JIP1 peptide<br /> | ||
| + | **[[6f5e]] - hMAPK8 JNK1+JIP1 peptide + darpin<br /> | ||
| + | **[[5lw1]] - hMAPK8 JNK1+JIP1 peptide + darpin + pepstatin<br /> | ||
**[[3v3v]] - hMAPK8 JNK1+JIP1 peptide + quercedagetin<br /> | **[[3v3v]] - hMAPK8 JNK1+JIP1 peptide + quercedagetin<br /> | ||
**[[3o2m]] - hMAPK8 (mutant)+JIP1 peptide+biaryl tetrazole<br /> | **[[3o2m]] - hMAPK8 (mutant)+JIP1 peptide+biaryl tetrazole<br /> | ||
| Line 100: | Line 104: | ||
*MAPK10 | *MAPK10 | ||
| - | **[[3kvx]], [[3fv8]], [[2waj]], [[3fi2]], [[3fi3]], [[3da6]], [[2zdt]], [[2zdu]], [[3cgf]], [[3cgo]], [[2r9s]], [[2o0u]], [[2o2u]], [[2exc]], [[2b1p]], [[1pmn]], [[4z9l]], [[1pmu]], [[1pmv]], [[3oy1]], [[2ok1]], [[3ttj]], [[3tti]], [[3rtp]], [[3v6r]], [[3v6s]], [[4kkh]], [[4u79]], [[4whz]], [[4x21]], [[4y46]], [[4y5h]] – hMAPK10+inhibitor<br /> | + | **[[3kvx]], [[3fv8]], [[2waj]], [[3fi2]], [[3fi3]], [[3da6]], [[2zdt]], [[2zdu]], [[3cgf]], [[3cgo]], [[2r9s]], [[2o0u]], [[2o2u]], [[2exc]], [[2b1p]], [[1pmn]], [[4z9l]], [[1pmu]], [[1pmv]], [[3oy1]], [[2ok1]], [[3ttj]], [[3tti]], [[3rtp]], [[3v6r]], [[3v6s]], [[4kkh]], [[4u79]], [[4whz]], [[4x21]], [[4y46]], [[4y5h]], [[3g9l]], [[3g90]], [[3g9n]], [[2p33]], [[6emh]], [[6ekd]] – hMAPK10 catalytic domain + inhibitor<br /> |
**[[3ptg]], [[4h39]] - hMAPK10 catalytic domain + JIP1 peptide <br /> | **[[3ptg]], [[4h39]] - hMAPK10 catalytic domain + JIP1 peptide <br /> | ||
**[[4h36]] – hMAPK10 catalytic domain + ATF2 peptide<br /> | **[[4h36]] – hMAPK10 catalytic domain + ATF2 peptide<br /> | ||
**[[4h3b]] – hMAPK10 catalytic domain + SAB peptide<br /> | **[[4h3b]] – hMAPK10 catalytic domain + SAB peptide<br /> | ||
**[[4kke]], [[4kkg]] – hMAPK10 catalytic domain + AMPPNP<br /> | **[[4kke]], [[4kkg]] – hMAPK10 catalytic domain + AMPPNP<br /> | ||
| - | **[[ | + | **[[6eq9]] – hMAPK10 catalytic domain + ACP<br /> |
**[[3oxi]] - hMAPK10 + MAPK8 interacting protein + inhibitor<br /> | **[[3oxi]] - hMAPK10 + MAPK8 interacting protein + inhibitor<br /> | ||
| Line 123: | Line 127: | ||
**[[2lgc]] – hMAPK14 – NMR<br /> | **[[2lgc]] – hMAPK14 – NMR<br /> | ||
**[[3od6]], [[3ody]], [[3odz]], [[3oef]], [[3p4k]], [[2fsl]], [[2fsm]], [[2fso]], [[2fst]], [[1r3c]], [[4e5a]], [[4geo]] – hMAPK14 (mutant)<br /> | **[[3od6]], [[3ody]], [[3odz]], [[3oef]], [[3p4k]], [[2fsl]], [[2fsm]], [[2fso]], [[2fst]], [[1r3c]], [[4e5a]], [[4geo]] – hMAPK14 (mutant)<br /> | ||
| - | **[[3new]], [[3ocg]], [[3mvl]], [[3mvm]], [[3nnu]], [[3nnv]], [[3nnw]], [[3nnx]], [[3nww]], [[3mpt]], [[3lhj]], [[3huc]], [[3itz]], [[3l8x]], [[3kf7]], [[3fi4]], [[3fkl]], [[3fkn]], [[3fko]], [[3fl4]], [[3fln]], [[3flq]], [[3fls]], [[3flw]], [[3fly]], [[3flz]], [[3fmh]], [[3fmj]], [[3fmk]], [[3fml]], [[3flm]], [[3fln]], [[3fsf]], [[3fsk]], [[3kq7]], [[3iph]], [[3hv4]], [[3hv5]], [[3hv6]], [[3hv7]], [[3k3i]], [[3hec]], [[3heg]], [[3gi3]], [[3hp2]], [[3hp5]], [[3hrb]], [[3ha8]], [[3gfe]], [[3hl7]], [[3hll]], [[3gcu]], [[3fc1]], [[3dt1]], [[3e92]], [[3e93]], [[3d7z]], [[3d83]], [[3ctq]], [[2puu]], [[3bx5]], [[3c5u]], [[2zaz]], [[2zb0]], [[2zb1]], [[2qd9]], [[2ewa]], [[2gfs]], [[2baj]], [[2bak]], [[2bal]], [[2baq]], [[1zyj]], [[1wbn]], [[1wbs]], [[1wbt]], [[1wbv]], [[1wbw]], [[1zz2]], [[1zzl]], [[1yqj]], [[1w7h]], [[1w82]], [[1w83]], [[1w84]], [[1oz1]], [[1ouk]], [[1ouy]], [[1m7q]], [[1kv1]], [[1kv2]], [[1di9]], [[2rg5]], [[2rg6]], [[3bv3]], [[3bv2]], [[3fmm]], [[3fmn]], [[3lfa]], [[3mw1]], [[3pg3]], [[3roc]] ,[[2yis]], [[2yiw]], [[2yix]], [[3qud]], [[3que]], [[3rin]], [[3s3i]], [[3s4q]], [[3u8w]], [[3uvp]], [[3uvq]], [[3uvr]], [[3zs5]], [[3zsg]], [[3zsh]], [[3zsi]], [[3zya]], [[4a9y]], [[4aa0]], [[4aa4]], [[4aa5]], [[4aac]], [[4dli]], [[4dlj]], [[4e5b]], [[4eh2]], [[4eh3]], [[4eh4]], [[4eh5]], [[4eh6]], [[4eh7]], [[4eh8]], [[4eh9]], [[4ehv]], [[4ewq]], [[4f9w]], [[4f9y]], [[4fa2]], [[4kin]], [[4kip]], [[4kiq]], [[4l8m]], [[4r3c]], [[4zth]], [[5lar]], [[5ml5]], [[5tbe]], [[5tco]] - hMAPK14+inhibitor<br /> | + | **[[3new]], [[3ocg]], [[3mvl]], [[3mvm]], [[3nnu]], [[3nnv]], [[3nnw]], [[3nnx]], [[3nww]], [[3mpt]], [[3lhj]], [[3huc]], [[3itz]], [[3l8x]], [[3kf7]], [[3fi4]], [[3fkl]], [[3fkn]], [[3fko]], [[3fl4]], [[3fln]], [[3flq]], [[3fls]], [[3flw]], [[3fly]], [[3flz]], [[3fmh]], [[3fmj]], [[3fmk]], [[3fml]], [[3flm]], [[3fln]], [[3fsf]], [[3fsk]], [[3kq7]], [[3iph]], [[3hv4]], [[3hv5]], [[3hv6]], [[3hv7]], [[3k3i]], [[3hec]], [[3heg]], [[3gi3]], [[3hp2]], [[3hp5]], [[3hrb]], [[3ha8]], [[3gfe]], [[3hl7]], [[3hll]], [[3gcu]], [[3fc1]], [[3dt1]], [[3e92]], [[3e93]], [[3d7z]], [[3d83]], [[3ctq]], [[2puu]], [[3bx5]], [[3c5u]], [[2zaz]], [[2zb0]], [[2zb1]], [[2qd9]], [[2ewa]], [[2gfs]], [[2baj]], [[2bak]], [[2bal]], [[2baq]], [[1zyj]], [[1wbn]], [[1wbs]], [[1wbt]], [[1wbv]], [[1wbw]], [[1zz2]], [[1zzl]], [[1yqj]], [[1w7h]], [[1w82]], [[1w83]], [[1w84]], [[1oz1]], [[1ouk]], [[1ouy]], [[1m7q]], [[1kv1]], [[1kv2]], [[1di9]], [[2rg5]], [[2rg6]], [[3bv3]], [[3bv2]], [[3fmm]], [[3fmn]], [[3lfa]], [[3mw1]], [[3pg3]], [[3roc]] ,[[2yis]], [[2yiw]], [[2yix]], [[3qud]], [[3que]], [[3rin]], [[3s3i]], [[3s4q]], [[3u8w]], [[3uvp]], [[3uvq]], [[3uvr]], [[3zs5]], [[3zsg]], [[3zsh]], [[3zsi]], [[3zya]], [[4a9y]], [[4aa0]], [[4aa4]], [[4aa5]], [[4aac]], [[4dli]], [[4dlj]], [[4e5b]], [[4eh2]], [[4eh3]], [[4eh4]], [[4eh5]], [[4eh6]], [[4eh7]], [[4eh8]], [[4eh9]], [[4ehv]], [[4ewq]], [[4f9w]], [[4f9y]], [[4fa2]], [[4kin]], [[4kip]], [[4kiq]], [[4l8m]], [[4r3c]], [[4zth]], [[5lar]], [[5ml5]], [[5tbe]], [[5tco]], [[6anl]], [[5xyy]], [[5xyx]] , [[5wjj]], [[5n68]], [[5n67]], [[5n66]], [[5n65]], [[5n64]], [[5n63]], [[5mz3]], [[5mty]], [[5mtx]], [[5o8v]], [[5o8u]] - hMAPK14+inhibitor<br /> |
**[[4e6a]], [[4e6c]], [[4e8a]] - hMAPK14+ lipid<br /> | **[[4e6a]], [[4e6c]], [[4e8a]] - hMAPK14+ lipid<br /> | ||
**[[3o8t]], [[3mpa]], [[3obg]], [[3o8u]], [[3o8p]], [[3obj]], [[3oc1]], [[3hub]], [[3l8s]], [[3hv3]], [[3iw5]], [[3iw6]], [[3iw7]], [[3iw8]], [[3k3j]], [[3gc7]], [[3gcp]], [[3gcq]], [[3gcs]], [[3gcv]], [[3ds6]], [[2i0h]], [[1ove]], [[3lfb]], [[3lfc]], [[3lfd]], [[3lfe]], [[3lff]], [[1bl6]], [[1bl7]], [[1bmk]], [[1a9u]], [[1ian]] - hMAPK14 (mutant)+inhibitor<br /> | **[[3o8t]], [[3mpa]], [[3obg]], [[3o8u]], [[3o8p]], [[3obj]], [[3oc1]], [[3hub]], [[3l8s]], [[3hv3]], [[3iw5]], [[3iw6]], [[3iw7]], [[3iw8]], [[3k3j]], [[3gc7]], [[3gcp]], [[3gcq]], [[3gcs]], [[3gcv]], [[3ds6]], [[2i0h]], [[1ove]], [[3lfb]], [[3lfc]], [[3lfd]], [[3lfe]], [[3lff]], [[1bl6]], [[1bl7]], [[1bmk]], [[1a9u]], [[1ian]] - hMAPK14 (mutant)+inhibitor<br /> | ||
| Line 137: | Line 141: | ||
**[[1lew]] - mMAPK14+MEF2A<br /> | **[[1lew]] - mMAPK14+MEF2A<br /> | ||
**[[1lez]] - mMAPK14+MKK3B<br /> | **[[1lez]] - mMAPK14+MKK3B<br /> | ||
| + | **[[5nzz]] – mMAPK14 + TGF <br /> | ||
| + | **[[5o90]] – mMAPK14 (mutant) + TGF peptide<br /> | ||
*MAPK Fus3 | *MAPK Fus3 | ||
Revision as of 09:14, 8 August 2018
| |||||||||||
3D Structures of Mitogen-activated protein kinase
Updated on 08-August-2018
References
- ↑ Robinson MJ, Cobb MH. Mitogen-activated protein kinase pathways. Curr Opin Cell Biol. 1997 Apr;9(2):180-6. PMID:9069255
- ↑ Aronov AM, Baker C, Bemis GW, Cao J, Chen G, Ford PJ, Germann UA, Green J, Hale MR, Jacobs M, Janetka JW, Maltais F, Martinez-Botella G, Namchuk MN, Straub J, Tang Q, Xie X. Flipped out: structure-guided design of selective pyrazolylpyrrole ERK inhibitors. J Med Chem. 2007 Mar 22;50(6):1280-7. Epub 2007 Feb 15. PMID:17300186 doi:http://dx.doi.org/10.1021/jm061381f
