2ong
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 2ong |SIZE=350|CAPTION= <scene name='initialview01'>2ong</scene>, resolution 2.7Å | |PDB= 2ong |SIZE=350|CAPTION= <scene name='initialview01'>2ong</scene>, resolution 2.7Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=FPG:(1S)-1-[(1R)-1-FLUOROETHYL]-1,5-DIMETHYLHEXYL+TRIHYDROGEN+DIPHOSPHATE'>FPG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2onh|2ONH]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ong FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ong OCA], [http://www.ebi.ac.uk/pdbsum/2ong PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ong RCSB]</span> | ||
}} | }} | ||
| Line 26: | Line 29: | ||
[[Category: Kang, C.]] | [[Category: Kang, C.]] | ||
[[Category: Youn, B.]] | [[Category: Youn, B.]] | ||
| - | [[Category: BTB]] | ||
| - | [[Category: FPG]] | ||
| - | [[Category: MN]] | ||
[[Category: 2 fluorogeranyl diphosphate]] | [[Category: 2 fluorogeranyl diphosphate]] | ||
[[Category: 2-fluorolinalyl diphosphate]] | [[Category: 2-fluorolinalyl diphosphate]] | ||
| Line 37: | Line 37: | ||
[[Category: monoterpene synthase]] | [[Category: monoterpene synthase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:20:20 2008'' |
Revision as of 01:20, 31 March 2008
| |||||||
| , resolution 2.7Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Related: | 2ONH
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of of limonene synthase with 2-fluorogeranyl diphosphate (FGPP).
Overview
The crystal structure of (4S)-limonene synthase from Mentha spic ata, a metal ion-dependent monoterpene cyclase that catalyzes the coupled isomerization and cyclization of geranyl diphosphate, is reported at 2.7-A; resolution in two forms liganded to the substrate and intermediate analogs, 2-fluorogeranyl diphosphate and 2-fluorolinalyl diphosphate, respectively. The implications of these findings are described for domain interactions in the homodimer and for changes in diphosphate-metal ion coordination and substrate binding conformation in the course of the multistep reaction.
About this Structure
2ONG is a Single protein structure of sequence from Mentha spicata. Full crystallographic information is available from OCA.
Reference
Structure of limonene synthase, a simple model for terpenoid cyclase catalysis., Hyatt DC, Youn B, Zhao Y, Santhamma B, Coates RM, Croteau RB, Kang C, Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5360-5. Epub 2007 Mar 19. PMID:17372193
Page seeded by OCA on Mon Mar 31 04:20:20 2008
