2onj
From Proteopedia
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|PDB= 2onj |SIZE=350|CAPTION= <scene name='initialview01'>2onj</scene>, resolution 3.400Å | |PDB= 2onj |SIZE=350|CAPTION= <scene name='initialview01'>2onj</scene>, resolution 3.400Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2onj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2onj OCA], [http://www.ebi.ac.uk/pdbsum/2onj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2onj RCSB]</span> | ||
}} | }} | ||
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[[Category: Dawson, R J.P.]] | [[Category: Dawson, R J.P.]] | ||
[[Category: Locher, K P.]] | [[Category: Locher, K P.]] | ||
| - | [[Category: ANP]] | ||
| - | [[Category: NA]] | ||
[[Category: integral membrane protein]] | [[Category: integral membrane protein]] | ||
[[Category: transport protein]] | [[Category: transport protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:20:21 2008'' |
Revision as of 01:20, 31 March 2008
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| , resolution 3.400Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of the multidrug ABC transporter Sav1866 from S. aureus in complex with AMP-PNP
Overview
Staphylococcus aureus Sav1866 is a bacterial homolog of the human ABC transporter Mdr1 that causes multidrug resistance in cancer cells. We report the crystal structure of Sav1866 in complex with adenosine-5'-(beta,gamma-imido)triphosphate (AMP-PNP) at 3.4A resolution and compare it with the previously determined structure of Sav1866 with bound ADP. Besides differences in the ATP-binding sites, no significant conformational changes were observed. The results confirm that the ATP-bound state of multidrug ABC transporters is coupled to an outward-facing conformation of the transmembrane domains.
About this Structure
2ONJ is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.
Reference
Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP., Dawson RJ, Locher KP, FEBS Lett. 2007 Mar 6;581(5):935-8. Epub 2007 Feb 7. PMID:17303126
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