2oo4
From Proteopedia
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|PDB= 2oo4 |SIZE=350|CAPTION= <scene name='initialview01'>2oo4</scene>, resolution 2.003Å | |PDB= 2oo4 |SIZE=350|CAPTION= <scene name='initialview01'>2oo4</scene>, resolution 2.003Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= NOTCH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= NOTCH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oo4 OCA], [http://www.ebi.ac.uk/pdbsum/2oo4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2oo4 RCSB]</span> | ||
}} | }} | ||
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[[Category: Sanchez-Irizarry, C.]] | [[Category: Sanchez-Irizarry, C.]] | ||
[[Category: Vardar-Ulu, D.]] | [[Category: Vardar-Ulu, D.]] | ||
| - | [[Category: | + | [[Category: alpha-beta-sandwich]] |
| - | [[Category: | + | [[Category: cysteine-rich]] |
| - | [[Category: | + | [[Category: hd domain]] |
| - | [[Category: | + | [[Category: lin12 notch repeat]] |
| + | [[Category: lnr]] | ||
| + | [[Category: sea domain]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:20:38 2008'' |
Revision as of 01:20, 31 March 2008
| |||||||
| , resolution 2.003Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Gene: | NOTCH2 (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of LNR-HD (Negative Regulatory Region) from human Notch 2
Contents |
Overview
Notch receptors transmit signals between adjacent cells. Signaling is initiated when ligand binding induces metalloprotease cleavage of Notch within an extracellular negative regulatory region (NRR). We present here the X-ray structure of the human NOTCH2 NRR, which adopts an autoinhibited conformation. Extensive interdomain interactions within the NRR bury the metalloprotease site, showing that a substantial conformational movement is necessary to expose this site during activation by ligand. Leukemia-associated mutations in NOTCH1 probably release autoinhibition by destabilizing the conserved hydrophobic core of the NRR.
Disease
Known disease associated with this structure: Alagille syndrome 2 OMIM:[600275]
About this Structure
2OO4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural basis for autoinhibition of Notch., Gordon WR, Vardar-Ulu D, Histen G, Sanchez-Irizarry C, Aster JC, Blacklow SC, Nat Struct Mol Biol. 2007 Apr;14(4):295-300. Epub 2007 Apr 1. PMID:17401372
Page seeded by OCA on Mon Mar 31 04:20:38 2008
