5ohw
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the truncated form of the third PDZ domain of PSD-95: residues 302-392== | |
| - | + | <StructureSection load='5ohw' size='340' side='right' caption='[[5ohw]], [[Resolution|resolution]] 1.55Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ohw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OHW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ohw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ohw OCA], [http://pdbe.org/5ohw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ohw RCSB], [http://www.ebi.ac.uk/pdbsum/5ohw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ohw ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Camara-Artigas, A]] | [[Category: Camara-Artigas, A]] | ||
| + | [[Category: Pdz domain]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 21:14, 9 August 2018
Crystal Structure of the truncated form of the third PDZ domain of PSD-95: residues 302-392
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