5oi6
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the third PDZ domain of PSD-95 protein D332P mutant: space group C121, structure 2== | |
| - | + | <StructureSection load='5oi6' size='340' side='right' caption='[[5oi6]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5oi6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OI6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OI6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oi6 OCA], [http://pdbe.org/5oi6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oi6 RCSB], [http://www.ebi.ac.uk/pdbsum/5oi6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oi6 ProSAT]</span></td></tr> | |
| - | [[ | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Camara-Artigas, A]] | [[Category: Camara-Artigas, A]] | ||
| + | [[Category: Pdz domain]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 21:14, 9 August 2018
Crystal Structure of the third PDZ domain of PSD-95 protein D332P mutant: space group C121, structure 2
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