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5yhn

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'''Unreleased structure'''
 
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The entry 5yhn is ON HOLD until Paper Publication
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==Solution structure of the LEKTI Domain 4==
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<StructureSection load='5yhn' size='340' side='right' caption='[[5yhn]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5yhn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YHN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YHN FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yhn OCA], [http://pdbe.org/5yhn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yhn RCSB], [http://www.ebi.ac.uk/pdbsum/5yhn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yhn ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Despite being initially identified in the blood filtrate, LEKTI is a 15-domain Kazal-type inhibitor mostly known in the regulation of skin desquamation. In the current study, screening of serine proteases in blood coagulation cascade showed that LEKTI domain 4 has inhibitory activity toward only FXIa, whereas LEKTI domain 6 inhibits both FXIa and FXaB (bovine FXa). Nuclear magnetic resonance structural and dynamic experiments plus molecular dynamics simulation revealed that LEKTI domain 4 has enhanced backbone flexibility at the reactive-site loop. A model of the LEKTI-protease complex revealed that FXaB has a narrower S4 pocket compared with FXIa and hence prefers only small side-chain residues at the P4 position, such as Ala in LEKTI domain 6. Mutational studies combined with a molecular complex model suggest that both a more flexible reactive-site loop and a bulky residue at the P4 position make LEKTI domain 4 a weaker but highly selective inhibitor of FXIa.
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Authors:
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Homologous Lympho-Epithelial Kazal-type Inhibitor Domains Delay Blood Coagulation by Inhibiting Factor X and XI with Differential Specificity.,Ramesh K, Lama D, Tan KW, Nguyen VS, Chew FT, Verma CS, Mok YK Structure. 2018 Jun 13. pii: S0969-2126(18)30205-3. doi:, 10.1016/j.str.2018.05.018. PMID:30017565<ref>PMID:30017565</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 5yhn" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Mok, Y K]]
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[[Category: Ramesh, K]]
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[[Category: Hydrolase inhibitor]]
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[[Category: Inhibitor]]
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[[Category: Kazal]]
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[[Category: Lekti]]

Revision as of 21:43, 9 August 2018

Solution structure of the LEKTI Domain 4

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