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6acc
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Trypsin-cleaved and low pH-treated SARS-CoV spike glycoprotein and ACE2 complex, ACE2-free conformation with three RBD in down conformation== | |
| - | + | <StructureSection load='6acc' size='340' side='right' caption='[[6acc]], [[Resolution|resolution]] 3.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6acc]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ACC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ACC FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6acc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6acc OCA], [http://pdbe.org/6acc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6acc RCSB], [http://www.ebi.ac.uk/pdbsum/6acc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6acc ProSAT]</span></td></tr> | |
| - | [[ | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SPIKE_CVHSA SPIKE_CVHSA]] S1 attaches the virion to the cell membrane by interacting with human ACE2 and CLEC4M/DC-SIGNR, initiating the infection. Binding to the receptor and internalization of the virus into the endosomes of the host cell probably induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes. S2 is a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Gui, M]] | [[Category: Gui, M]] | ||
[[Category: Song, W]] | [[Category: Song, W]] | ||
| + | [[Category: Class i fusion protein]] | ||
| + | [[Category: Glycoprotein]] | ||
| + | [[Category: Membrane fusion]] | ||
| + | [[Category: Sars-cov]] | ||
| + | [[Category: Spike]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 21:45, 9 August 2018
Trypsin-cleaved and low pH-treated SARS-CoV spike glycoprotein and ACE2 complex, ACE2-free conformation with three RBD in down conformation
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