6gf2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "6gf2" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6gf2 is ON HOLD
+
==The structure of the ubiquitin-like modifier FAT10 reveals a novel targeting mechanism for degradation by the 26S proteasome==
-
 
+
<StructureSection load='6gf2' size='340' side='right' caption='[[6gf2]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
-
Authors:
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[6gf2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GF2 FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gf2 OCA], [http://pdbe.org/6gf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gf2 RCSB], [http://www.ebi.ac.uk/pdbsum/6gf2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gf2 ProSAT]</span></td></tr>
-
[[Category: Unreleased Structures]]
+
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/UBD_HUMAN UBD_HUMAN]] Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN).<ref>PMID:15831455</ref> <ref>PMID:16495380</ref> <ref>PMID:16495226</ref> <ref>PMID:17889673</ref> <ref>PMID:19033385</ref> <ref>PMID:18574467</ref> <ref>PMID:19166848</ref> <ref>PMID:19028597</ref> <ref>PMID:19726511</ref> <ref>PMID:19959714</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Aichem, A]]
 +
[[Category: Anders, S]]
 +
[[Category: Berg, A]]
 +
[[Category: Bialas, J]]
 +
[[Category: Catone, N]]
 +
[[Category: Groettrup, M]]
 +
[[Category: Peter, C]]
 +
[[Category: Roessler, P]]
 +
[[Category: Scheuermann, S]]
 +
[[Category: Schmidtke, G]]
 +
[[Category: Schwab, R]]
 +
[[Category: Stotz, S]]
 +
[[Category: Wiesner, S]]
 +
[[Category: Degradation]]
 +
[[Category: Fat10]]
 +
[[Category: Immune system]]
 +
[[Category: Proteasome]]
 +
[[Category: Ubiquitin-like modifier]]

Revision as of 21:55, 9 August 2018

The structure of the ubiquitin-like modifier FAT10 reveals a novel targeting mechanism for degradation by the 26S proteasome

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6gf2"
Personal tools