6gy5
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the kelch domain of human KLHL20 in complex with DAPK1 peptide== | |
| - | + | <StructureSection load='6gy5' size='340' side='right' caption='[[6gy5]], [[Resolution|resolution]] 1.09Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6gy5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GY5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GY5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gy5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gy5 OCA], [http://pdbe.org/6gy5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gy5 RCSB], [http://www.ebi.ac.uk/pdbsum/6gy5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gy5 ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/KLH20_HUMAN KLH20_HUMAN]] Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis (PubMed:20389280). The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination (PubMed:24768539). Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking (PubMed:24768539). Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (PubMed:21670212). In case of tumor, the BCR(KLHL20) E3 ubiquitin ligase complex is involved in tumor hypoxia: following hypoxia, the BCR(KLHL20)complex mediates ubiquitination and degradation of PML, potentiating HIF-1 signaling and cancer progression (PubMed:21840486).<ref>PMID:14528312</ref> <ref>PMID:17395875</ref> <ref>PMID:20389280</ref> <ref>PMID:21670212</ref> <ref>PMID:21840486</ref> <ref>PMID:24768539</ref> |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Bullock, A N]] | ||
[[Category: Burgess-Brown, N]] | [[Category: Burgess-Brown, N]] | ||
| + | [[Category: Carpenter, E P]] | ||
| + | [[Category: Chen, Z]] | ||
| + | [[Category: Cooper, C D.O]] | ||
| + | [[Category: Delft, F von]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Fairhead, M]] | ||
[[Category: Hozjan, V]] | [[Category: Hozjan, V]] | ||
| - | [[Category: Williams, E]] | ||
| - | [[Category: Fairhead, M]] | ||
| - | [[Category: Wang, D]] | ||
| - | [[Category: Von Delft, F]] | ||
| - | [[Category: Bullock, A.N]] | ||
| - | [[Category: Edwards, A.M]] | ||
[[Category: Johansson, C]] | [[Category: Johansson, C]] | ||
| - | [[Category: Chen, Z]] | ||
| - | [[Category: Strain-Damerell, C]] | ||
[[Category: Krojer, T]] | [[Category: Krojer, T]] | ||
| - | [[Category: | + | [[Category: Mathea, S]] |
| + | [[Category: Pike, A C.W]] | ||
| + | [[Category: Sanvitale, C E]] | ||
| + | [[Category: Sorrell, F]] | ||
[[Category: Srikannathasan, V]] | [[Category: Srikannathasan, V]] | ||
| - | [[Category: | + | [[Category: Strain-Damerell, C]] |
| - | [[Category: | + | [[Category: Wang, D]] |
| - | [[Category: | + | [[Category: Williams, E]] |
| + | [[Category: Complex]] | ||
| + | [[Category: Death domain]] | ||
| + | [[Category: E3 ligase]] | ||
| + | [[Category: Kelch domain]] | ||
| + | [[Category: Ligase]] | ||
| + | [[Category: Substrate]] | ||
| + | [[Category: Ubiquitination]] | ||
Revision as of 21:58, 9 August 2018
Crystal structure of the kelch domain of human KLHL20 in complex with DAPK1 peptide
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Categories: Arrowsmith, C H | Bountra, C | Bullock, A N | Burgess-Brown, N | Carpenter, E P | Chen, Z | Cooper, C D.O | Delft, F von | Edwards, A M | Fairhead, M | Hozjan, V | Johansson, C | Krojer, T | Mathea, S | Pike, A C.W | Sanvitale, C E | Sorrell, F | Srikannathasan, V | Strain-Damerell, C | Wang, D | Williams, E | Complex | Death domain | E3 ligase | Kelch domain | Ligase | Substrate | Ubiquitination
