Neuraminidase
From Proteopedia
(Difference between revisions)
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**[[3sil]] – StNANA (mutant) – ''Salmonella typhimurium''<br /> | **[[3sil]] – StNANA (mutant) – ''Salmonella typhimurium''<br /> | ||
**[[4bbw]], [[5muk]] – BtNAN – ''Bacterioides thetaiotaomicron''<br /> | **[[4bbw]], [[5muk]] – BtNAN – ''Bacterioides thetaiotaomicron''<br /> | ||
| + | **[[5tsp]] - NANI + CHES – ''Clostridium perfringens''<br /> | ||
| - | * | + | *Complexes of Neuraminidase |
**[[3h72]] - SpNANA catalytic domain precursor + sialic derivative<br /> | **[[3h72]] - SpNANA catalytic domain precursor + sialic derivative<br /> | ||
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**[[4foq]], [[4fov]], [[4fow]], [[4foy]], [[4fp2]], [[4fp3]], [[4fpc]], [[4fpe]], [[4fpf]], [[4fpg]], [[4fph]], [[4fpj]], [[4fpk]], [[4fpl]], [[4fpo]], [[4fpy]], [[4fq4]] – SpNANB + inhibitor<br /> | **[[4foq]], [[4fov]], [[4fow]], [[4foy]], [[4fp2]], [[4fp3]], [[4fpc]], [[4fpe]], [[4fpf]], [[4fpg]], [[4fph]], [[4fpj]], [[4fpk]], [[4fpl]], [[4fpo]], [[4fpy]], [[4fq4]] – SpNANB + inhibitor<br /> | ||
**[[4xyx]] – SpNANB + drug<br /> | **[[4xyx]] – SpNANB + drug<br /> | ||
| + | **[[4yw2]] – SpNANB residues 83-740 + sialic acid<br /> | ||
**[[4xog]], [[4xjw]], [[4xj9]], [[4xil]], [[4xe9]] – SpNANB (mutant) + drug<br /> | **[[4xog]], [[4xjw]], [[4xj9]], [[4xil]], [[4xe9]] – SpNANB (mutant) + drug<br /> | ||
**[[4xju]], [[4xja]], [[4xhx]], [[4xhb]] – SpNANB (mutant) + inhibitor<br /> | **[[4xju]], [[4xja]], [[4xhx]], [[4xhb]] – SpNANB (mutant) + inhibitor<br /> | ||
**[[4yz2]], [[4yw3]], [[4wy2]], [[4wy1]] – SpNANC + inhibitor<br /> | **[[4yz2]], [[4yw3]], [[4wy2]], [[4wy1]] – SpNANC + inhibitor<br /> | ||
| + | **[[4yw1]] – SpNANC residues 83-740 + sialic acid + neuraminic acid derivative <br /> | ||
**[[4yz3]], [[4yw5]] – SpNANC + drug<br /> | **[[4yz3]], [[4yw5]] – SpNANC + drug<br /> | ||
| + | **[[6eku]], [[6eks]] – VcNANC + drug<br /> | ||
**[[1w0p]] – VcNANA + sialic derivative<br /> | **[[1w0p]] – VcNANA + sialic derivative<br /> | ||
**[[2f0z]], [[2f10]], [[2f11]], [[2f12]], [[2f13]] – hNeu2 + inhibitor<br /> | **[[2f0z]], [[2f10]], [[2f11]], [[2f12]], [[2f13]] – hNeu2 + inhibitor<br /> | ||
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**[[1f8b]], [[1inv]], [[1inw]], [[1inx]], [[1iny]], [[4gb1]] – IvNANA + sialic acid analog<br /> | **[[1f8b]], [[1inv]], [[1inw]], [[1inx]], [[1iny]], [[4gb1]] – IvNANA + sialic acid analog<br /> | ||
**[[3ti3]], [[3ti4]], [[3ti5]], [[3ti6]] – IvNAN H1n1 + inhibitor<br /> | **[[3ti3]], [[3ti4]], [[3ti5]], [[3ti6]] – IvNAN H1n1 + inhibitor<br /> | ||
| - | **[[4b7j]], [[4b7n]], [[4b7q]], [[4b7r]] - IvNAN H1n1 + drug<br /> | + | **[[4b7j]], [[4b7n]], [[4b7q]], [[4b7r]], [[5nzn]] - IvNAN H1n1 + drug<br /> |
**[[4qnp]] - IvNAN H1n1 + antibody<br /> | **[[4qnp]] - IvNAN H1n1 + antibody<br /> | ||
| + | **[[5nzf]], [[5nze]], [[5nz4]], [[5nwe]] - IvNAN H1n1 (mutant) + drug<br /> | ||
**[[3tia]], [[3tib]], [[3tic]] – IvNAN H2n2 + inhibitor<br /> | **[[3tia]], [[3tib]], [[3tic]] – IvNAN H2n2 + inhibitor<br /> | ||
**[[2bat]], [[4gzw]], [[4gzx]], [[4gzq]] – IvNAN H3n2 + sialic acid<br /> | **[[2bat]], [[4gzw]], [[4gzx]], [[4gzq]] – IvNAN H3n2 + sialic acid<br /> | ||
| - | **[[4gzp]], [[4gzt]] - IvNAN H3n2 + drug<br /> | + | **[[4gzp]], [[4gzt]], [[6br6]], [[6br5]] - IvNAN H3n2 + drug<br /> |
**[[4qn6]] - IvNAN H3n6 + drug<br /> | **[[4qn6]] - IvNAN H3n6 + drug<br /> | ||
**[[4wa5]], [[4wa4]] - IvNAN H3n8 + drug<br /> | **[[4wa5]], [[4wa4]] - IvNAN H3n8 + drug<br /> | ||
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**[[4mwq]], [[4mwr]], [[4mwu]], [[4mwv]], [[4mww]], [[4mwx]], [[4mwy]], [[4mx0]] - IvNAN H7n9 + flu drug<br /> | **[[4mwq]], [[4mwr]], [[4mwu]], [[4mwv]], [[4mww]], [[4mwx]], [[4mwy]], [[4mx0]] - IvNAN H7n9 + flu drug<br /> | ||
**[[4qn7]]- IvNAN H10n7 + drug<br /> | **[[4qn7]]- IvNAN H10n7 + drug<br /> | ||
| - | **[[1nna]], [[1nnb]] - IvNAN H11n9 + neuraminic acid derivative<br /> | + | **[[1nna]], [[1nnb]], [[5w2y]], [[5w2w]], [[5w2u]], [[5w26]] - IvNAN H11n9 + neuraminic acid derivative<br /> |
**[[4dgr]] - IvNAN H11n9 + benzoic acid derivative<br /> | **[[4dgr]] - IvNAN H11n9 + benzoic acid derivative<br /> | ||
**[[4weg]] - IvNAN H11n9 + sialic acid derivative <br /> | **[[4weg]] - IvNAN H11n9 + sialic acid derivative <br /> | ||
Revision as of 06:42, 13 August 2018
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3D structures of Neuraminidase
Updated on 13-August-2018
References
- ↑ Matrosovich MN, Matrosovich TY, Gray T, Roberts NA, Klenk HD. Neuraminidase is important for the initiation of influenza virus infection in human airway epithelium. J Virol. 2004 Nov;78(22):12665-7. PMID:15507653 doi:http://dx.doi.org/10.1128/JVI.78.22.12665-12667.2004
- ↑ Rutishauser U, Watanabe M, Silver J, Troy FA, Vimr ER. Specific alteration of NCAM-mediated cell adhesion by an endoneuraminidase. J Cell Biol. 1985 Nov;101(5 Pt 1):1842-9. PMID:4055897
- ↑ Colli W. Trans-sialidase: a unique enzyme activity discovered in the protozoan Trypanosoma cruzi. FASEB J. 1993 Oct;7(13):1257-64. PMID:8405811
- ↑ Sylte MJ, Suarez DL. Influenza neuraminidase as a vaccine antigen. Curr Top Microbiol Immunol. 2009;333:227-41. doi: 10.1007/978-3-540-92165-3_12. PMID:19768409 doi:http://dx.doi.org/10.1007/978-3-540-92165-3_12
- ↑ Schenkman S, Eichinger D, Pereira ME, Nussenzweig V. Structural and functional properties of Trypanosoma trans-sialidase. Annu Rev Microbiol. 1994;48:499-523. PMID:7826016 doi:http://dx.doi.org/10.1146/annurev.mi.48.100194.002435
- ↑ Russell RJ, Haire LF, Stevens DJ, Collins PJ, Lin YP, Blackburn GM, Hay AJ, Gamblin SJ, Skehel JJ. The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Nature. 2006 Sep 7;443(7107):45-9. Epub 2006 Aug 16. PMID:16915235 doi:http://dx.doi.org/10.1038/nature05114
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