NK cell receptor

From Proteopedia

Revision as of 07:53, 15 August 2018

spinqualitylabelsall models Human NK cell receptor NKG2D (grey and green) complex with class I MHC-like ligand ULBP3 (pink) and glutathione (PDB entry 1kcg) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Natural killer (NK) cell receptors are located on the innate immune system NK cells. The receptors are differentiated into those activating effector function and those inhibiting it. The receptors induce apoptosis upon binding ligands which indicate infection[1]. NKG2D is expressed in NK cells, cytotoxic T cells and T cell subsets. NKP are CD122(+) NK cell precursors. 2B4 (CD244) are expressed on all NK cells, T cell subset, monocytes and basophils[2]. Ly49 are lectin-type receptors expressed in NK cells and T cell subsets[3]. KIR are immunoglobulin-type receptors[4]. Relevance NKG2D is associated with response to cellular distress and infection[5].

3D structures of NK cell receptor

Updated on 15-August-2018

extracellular domain + MHC class I antigen B + β-2-microglobulin + IG κ chain C region

References

1. ↑ Lanier LL. NK cell receptors. Annu Rev Immunol. 1998;16:359-93. PMID:9597134 doi:http://dx.doi.org/10.1146/annurev.immunol.16.1.359
2. ↑ Mathew SO, Rao KK, Kim JR, Bambard ND, Mathew PA. Functional role of human NK cell receptor 2B4 (CD244) isoforms. Eur J Immunol. 2009 Jun;39(6):1632-41. doi: 10.1002/eji.200838733. PMID:19499526 doi:http://dx.doi.org/10.1002/eji.200838733
3. ↑ Kane KP, Lavender KJ, Ma BJ. Ly-49 receptors and their functions. Crit Rev Immunol. 2004;24(5):321-48. PMID:15663362
4. ↑ Norman PJ, Carrington CV, Byng M, Maxwell LD, Curran MD, Stephens HA, Chandanayingyong D, Verity DH, Hameed K, Ramdath DD, Vaughan RW. Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations. Genes Immun. 2002 Apr;3(2):86-95. PMID:11960306 doi:http://dx.doi.org/10.1038/sj.gene.6363836
5. ↑ Raulet DH. Roles of the NKG2D immunoreceptor and its ligands. Nat Rev Immunol. 2003 Oct;3(10):781-90. PMID:14523385 doi:http://dx.doi.org/10.1038/nri1199