2oxr
From Proteopedia
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|PDB= 2oxr |SIZE=350|CAPTION= <scene name='initialview01'>2oxr</scene>, resolution 2.40Å | |PDB= 2oxr |SIZE=350|CAPTION= <scene name='initialview01'>2oxr</scene>, resolution 2.40Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5'-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= pab0955 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29292 Pyrococcus abyssi]) | |GENE= pab0955 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29292 Pyrococcus abyssi]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1yrb|1YRB]], [[1yra|1YRA]], [[1yr9|1YR9]], [[1yr8|1YR8]], [[1yr7|1YR7]], [[1yr6|1YR6]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oxr OCA], [http://www.ebi.ac.uk/pdbsum/2oxr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2oxr RCSB]</span> | ||
}} | }} | ||
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[[Category: Gras, S.]] | [[Category: Gras, S.]] | ||
[[Category: Housset, D.]] | [[Category: Housset, D.]] | ||
| - | [[Category: GDP]] | ||
| - | [[Category: MG]] | ||
[[Category: gdp]] | [[Category: gdp]] | ||
[[Category: gtp binding protein]] | [[Category: gtp binding protein]] | ||
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[[Category: rossman fold]] | [[Category: rossman fold]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:24:49 2008'' |
Revision as of 01:24, 31 March 2008
| |||||||
| , resolution 2.40Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | pab0955 (Pyrococcus abyssi) | ||||||
| Related: | 1YRB, 1YRA, 1YR9, 1YR8, 1YR7, 1YR6
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
PAB0955 crystal structure : a GTPase in GDP and Mg bound form from Pyrococcus abyssi (after GTP hydrolysis)
Overview
The human XAB1/MBDin GTPase and its close homologues form one of the ten phylogenetically distinct families of the SIMIBI (after signal recognition particle, MinD and BioD) class of phosphate-binding loop NTPases. The genomic context and the partners identified for the archaeal and eukaryotic homologues indicate that they are involved in genome maintenance--DNA repair or replication. The crystal structure of PAB0955 from Pyrococcus abyssi shows that, unlike other SIMIBI class G proteins, these highly conserved GTPases are homodimeric, regardless of the presence of nucleotides. The nucleotide-binding site of PAB0955 is rather rigid and its conformation is closest to that of the activated SRP G domain. One insertion to the G domain bears a strictly conserved GPN motif, which is part of the catalytic site of the other monomer and stabilizes the phosphate ion formed. Owing to this unique functional feature, we propose to call this family as GPN-loop GTPase.
About this Structure
2OXR is a Single protein structure of sequence from Pyrococcus abyssi. Full crystallographic information is available from OCA.
Reference
Structural insights into a new homodimeric self-activated GTPase family., Gras S, Chaumont V, Fernandez B, Carpentier P, Charrier-Savournin F, Schmitt S, Pineau C, Flament D, Hecker A, Forterre P, Armengaud J, Housset D, EMBO Rep. 2007 Jun;8(6):569-75. Epub 2007 Apr 20. PMID:17468740
Page seeded by OCA on Mon Mar 31 04:24:49 2008
